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GI - 2 > Laxative Agents > Flashcards

Laxative Agents Flashcards

1
Q

5 classes of laxative agents?

A
  1. Bulk forming
  2. Stool softening
  3. Stimulants
  4. Saline agents
  5. Osmotic agents
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2
Q

5 classes of laxative agents?

A
  1. Bulk forming
  2. Stool softening
  3. Stimulants
  4. Saline agents
  5. Osmotic agents
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3
Q

5 items in the Bulk forming class?

A 
Diet items
Psyllium
Methylcellulose
Carboxymethylcellulose
Ca++ Polycarbophil
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4
Q

5 items in the Bulk forming class?

A 
Diet items
Psyllium
Methylcellulose
Carboxymethylcellulose
Ca++ Polycarbophil
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5
Q

MOA for Bulk forming class?

A

Increase bulk volume to increase GI motility

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6
Q

Adverse effects of the Bulk forming class?

A

Bloating and obstruction

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7
Q

Does the Bulk forming class have any drug interactions?

A

Yes - avoid co-administration

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8
Q

2 drugs in the Stool Softening class?

A 
Mineral oil
Docusate salts (na+ and ca++)
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9
Q

2 drugs in the Stool Softening class?

A 
Mineral oil
Docusate salts (na+ and ca++)
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10
Q

MOA for the Stool Softening class?

A

Surfactants - soften/lubricate stool

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11
Q

Does the Stool Softening class have laxative effects?

A

NO - just soften

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12
Q

Mineral oil penetrates?

A

Stool to soften

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13
Q

4 drugs in the Stimulants class?

A

Senna
Bisacodyl
Glycerin
Sodium Picosulfate

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14
Q

4 drugs in the Stimulants class?

A

Senna
Bisacodyl
Glycerin
Sodium Picosulfate

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15
Q

MOA for the Stimulants class?

A

Irritate enterocytes to stimulate peristalsis quickly

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16
Q

Adverse effects of the Stimulants class?

A

Cramping

Senna = urine discoloration

17
Q

Which Stimulant can cause urine discoloration?

A

Senna

18
Q

Which Stimulant is used for Pre-Colonoscopy Bowel Prep?

A

Sodium Picosulfate

19
Q

3 Saline Agents?

A

Mg++, K+, Na+ salts

20
Q

3 Saline Agents?

A

Mg++, K+, Na+ salts

21
Q

MOA for the Saline and Osmotic Agents?

A

Retain water in the GI tract

22
Q

MOA for the Saline and Osmotic Agents?

A

Retain water in the GI tract

23
Q

All of the Saline Agents can be used in combination for?

A

Pre-Colonoscopy Bowel Prep

24
Q

What drug interactions do the Saline Agents have?

A

Diuretics – electrolyte imbalances

25
Q

In what 2 conditions should you use caution when giving Saline Agents due to the possibility of electrolyte imbalances?

A

Renal Disease

CHF/HTN

26
Q

In what 2 conditions should you use caution when giving Saline Agents due to the possibility of electrolyte imbalances?

A

Renal Disease

CHF/HTN

27
Q

4 Osmotic Agents?

A

Lactulose
Lactitol
Polyethylene Glycol
Sorbitol

28
Q

4 Osmotic Agents?

A

Lactulose
Lactitol
Polyethylene Glycol
Sorbitol

29
Q

Adverse effects of Osmotic Agents?

A

Electrolyte disturbances

30
Q

What Osmotic Agent can be used for severe liver disease (Hyperammonemia) and why?

A

Lactulose

- Traps Ammonia in GI due to pH change

31
Q

What Osmotic Agent can be used for severe liver disease (Hyperammonemia) and why?

A

Lactulose

- Traps Ammonia in GI due to pH change

32
Q

What Osmotic Agent can be used for Pre-Colonoscopy Bowel Prep?

A

Polyethylene Glycol

33
Q

What laxatives can be used for Pre-Colonoscopy Bowel Prep?

A 
Sodium Picosulfate (Stimulant)
ALL Saline agents (mg++, k+, na+ salts)
Polyethylene Glycol (Osmotic agent)
34
Q

What laxatives can be used for Pre-Colonoscopy Bowel Prep?

A 
Sodium Picosulfate (Stimulant)
ALL Saline agents (mg++, k+, na+ salts)
Polyethylene Glycol (Osmotic agent)

GI - 2 (61 decks)

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