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Exotic and Laboratory Animals > Laboratory Mice > Flashcards

Laboratory Mice Flashcards

1
Q

What are the advantages of using mice in research?

A 
Small 
Low cost
Biology is well understood 
Can be genetically manipulated
Short life span = studies end sooner
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2
Q

What is the common name of Mus musculus

A

Swiss Albino mouse or House mouse

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3
Q

What is the common name of Peromyscus?

A

Deer or cotton mouse

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4
Q

What is the common name of Mus musculus musculus?

A

Eastern Europe Mouse

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5
Q

What is the common name of Mus musculus domesticus?

A

Western Europe mouse

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6
Q

What is the common name of Mus musculus castaneus?

A

Southeast Asia mouse

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7
Q

What is the common name of the Mus musculus molossinus?

A

Japan mouse

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8
Q

What is the life span of a mouse?

A

12-36 months

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9
Q

What is the age of puberty?

A

5-8 weeks

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10
Q

What is the length of the estrus cycle?

A

4-5 days

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11
Q

What is the length of gestation of mice?

A

19-21 days

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12
Q

What is the average litter size of mice?

A

7-11 (4-12+)

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13
Q

What is the weaning age of mice?

A

18-21 days

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14
Q

What gland do mice have that rats also possess?

A

Harderian gland

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15
Q

Where do mice have a high venous blood supply?

A

Orbital sinus

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16
Q

Mice are Coprophagic, which means they need to eat their feces to recover what vitamin?

A

B vitamin complex

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17
Q

Can mice vomit?

A

No.

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18
Q

How many pairs of mammary glands do mice have?

A

5

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19
Q

How many digits do mice have on their forelimb?

A

4

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20
Q

How many digits do mice have on their hind limbs?

A

5

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21
Q

What effect describes Housing female mice in groups will result in synchronization of their estrus cycles. Prolonged absence of male pheromones results in a state of anestrus (lack of a normal estrus cycle).

A

Lee Boot Effect

22
Q

What allows for timed mating of large group of females when females are housed together without a male and then begin estrus within 3 days when exposed to a male or the odor of a male?

A

Whitten Effect

23
Q

What effect describes If a pregnant female mouse is exposed to a new male or its odor within 4 days of breeding, the existing pregnancy will usually be aborted and the female will return to estrus.

A

Bruce Effect

24
Q

What term describes The developmental arrest induced by environmental conditions related to the survival of the dam and her ability to nourish developing embryos. * Females that are bred postpartum estrus have an extended gestation period. *

A

Facultative Diapause

25
Q

What are the young called?

A

Pups

26
Q

What are breeding females called?

A

Moms

27
Q

What do the pups look like by 1 week of age?

A

Hair has grown in

28
Q

What do pups look like at 2 weeks of age?

A

Eyes are open

Can see eyes open as early as 12 days

29
Q

How old are the pups when moist food can be given so they can begin weaning

A

15 days

30
Q

Hybrid

A

2 inbred strains bred

31
Q

Outbred

A

Stock

Randomly bred

32
Q

KO

A

Genetically engineered

One or more genes have been turned off through a targeted mutation

33
Q

Inbred

A

Homozygous Strain

20 generations

34
Q

Transgenic

A

Removing DNA sequences and inserting them into an ovum

35
Q

Stocks and Strains Outbred and Inbred: Swiss Webster

A

Albino

Outbred

36
Q

Stocks and Strains Outbred: CD-1

A

Albino

Outbred

37
Q

Stocks and Strains Inbred: C57-BL

A

Black

Inbred

38
Q

Stocks and Strains Inbred: DBA/2

A

Gray

Inbred

39
Q

Stocks and Strains Inbred: Balb/C

A

Albino

Inbred

40
Q

Stocks and Strains Inbred: SCID

A

Albino

Severe combined immunodeficient

41
Q

Stocks and Strains Inbred: Nu/nu

A

Athymic nude mice

42
Q

SCID mice

A

Severely compromised immuno deficient

Lack B & T cells

43
Q

Nude Mice

A

Lacks B cells

Lack Thymus gland

44
Q

What is the ideal temperature mice should be kept in?

A

65 to 85 degrees F

45
Q

What is the ideal humidity mice should be kept in?

A

40% to 60%

46
Q

How much water do mice need to consume per day?

A

15mL per 100g of body weight

47
Q

How much food do mice need to consume per day?

A

12-18g of food per 100g of body weight

48
Q

Why should you never pick a mouse up by grasping the middle or tip of the tail?

A

The scales can slough off result in a severe de-gloving injury

49
Q

What percentage of blood volume should not be removed at one sampling?

A

10%

50
Q

What is the blood volume of a mouse?

A

8% of the body weight

Exotic and Laboratory Animals (22 decks)

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