MODY and Neonatal Diabetes Flashcards

1
Q

MODY stands for what?

A

Maturity Onset diabetes of the young

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2
Q

MODY subtype of what condition?

A

T2DM

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3
Q

surgical sieve MODY?

A

genetic

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4
Q

MODY:

is there obesity?

A

no

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5
Q

MODY:

is there ketosis?

A

no

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6
Q

what inheritance pattern is MODY?

A

autosomal dominant

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7
Q

is MODY rare or common?

A

rare

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8
Q

MODY mild or severe disease?

A

mild

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9
Q

usual Mx?

A

no medication needed, just control diet better.

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10
Q

what gene commonly mutated in MODY 3?

A

HNF1A

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11
Q

Neonatal Diabetes is a subtype of what condition?

A

T2DM

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12
Q

how man types of neonatal diabetes are there?

A

2

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13
Q

which type of neonatal diabetes is milder?

A

type 2

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14
Q

which type of neonatal diabetes is permanent?

A

type 1

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15
Q

treatment for type 1 neonatal diabetes?

how long will they be on this treatment?

A

insulin

rest of their life

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16
Q

which type of neonatal diabetes is transient?

A

type 2

17
Q

outline pathophys of type 1 neonatal diabetes?

- step by step

A

IUGR > pancreas underdeveloped > Beta cells not making insulin > symptomatic hyperglycaemia > ketoacidosis

18
Q

outline pathophys of type 2 neonatal diabetes?
- step by step

type 2 neonatal diabetes usually resolves by when?

A

severe IUGR > pancreas underdeveloped > Beta cells make a little bit of insulin> symptomatic hyperglycaemia >

… but usually resolves by 18 months

19
Q

child has type 2 neonatal diabetes,

when will they become hyperglycaemic?

A

during illness

20
Q

which type of neonatal diabetes is some insulin made (but only a little ovo)?

A

type 2