106: GORD

Question 1

What is Barrett’s Oesophagus?

Answer 1

Metaplasic mucosa forms where squamous sould be in the oesophagus cut to gastric acid damage

Question 2

cells in the gastric body mucosa…

Answer 2

chief and parietal calls

Question 3

glandular tumour nomenclature…

Answer 3

adenocarcinoma

Question 4

smooth muscle tumour….

Answer 4

leiomyosarcoma

Question 5

skeletal muscle tumour…

Answer 5

rhabdomyosarcoma

Question 6

bone tumour…

Answer 6

osteosarcoma

Question 7

cartilage tumour..

Answer 7

chondrosarcoma

Question 8

fibrous tissue tumour…

Answer 8

fibrosarcoma

Question 9

vascular tumour…

Answer 9

angiosarcoma

Question 10

melanocytes tumour…

Answer 10

malignant melanoma

Question 11

peptic ulcer symptoms

Answer 11

dyspepsia, weight loss, anorexia, IBS. GU - after meals, DU- 2-5h post meal/empty stomach

Question 12

ulcer causes

Answer 12

NSAIDS ( reduce COX 1 levels - reduced protective prostaglandins)
Helicobacter Pylori ( antral gastritis cuases DU, pan gastritis - GU)
smoking
stress/diet/familial

Question 13

how do proton pump inhibitors work?

Answer 13

inhibit H transport from parietal cells

Question 14

what is Meckel’s Diverticulum

Answer 14

embryological malformation of distal ileum

Question 15

What is Stevens-Johnson Syndrome?

Answer 15

autoimmune hypersensitivity disorder causing target skin lesions

Question 16

What is achalasia?

Answer 16

condition affecting the nerves and muscles of the oesophagus - affecting swallowing.

Question 17

what do antacids do?

Answer 17

neutralise acid production

Question 18

what to alginates do?

Answer 18

reduce irritancy of acid

Question 19

what do sucralfates do?

Answer 19

promote mucosal defence via prostaglandin receptor

Question 20

what does metoclopramide and domperidone do?

Answer 20

gastric stimulant - peristalsis

Question 21

what do proton pump inhibitors and H2 receptor agonists do?

Answer 21

reduce acid production.

Question 22

name a sucralfate…

Answer 22

misoprostol

Question 23

name some H2 receptor agonists

Answer 23

ranitidine, nizatidine, famotidine, cimetidine

Question 24

name some proton pump inhibitors

Answer 24

omeprazole, lansoprazole, pantoprazole, esomeprazole

Question 25

treatment of h pylori

Answer 25

omeprazole, amoxicillin and clarithromycin

Question 26

constipation from antacids likely de due to

Answer 26

aluminium

Question 27

what should not be prescribed for a woman of childbearing age for acid reflux?

Answer 27

misoprostol

Question 28

what has a protective effect on gastrointestinal mucosa?

Answer 28

prostaglandins

Question 29

long term use of PPI is associated with

Answer 29

c diff, osterporosis, community acquired pneumonia

Question 30

which medications cause dyspepsia in some patients ?

Answer 30

calcium channel blockers

Question 31

ranitidine blocks the action of which substrate on the receptor?

Answer 31

histamine

Question 32

m3 receptors receive which substrate?

Answer 32

acetyl choline

Question 33

CCk2 receptors receive which substrate

Answer 33

gastrin