205: Alcoholism and Hepatitis Flashcards
(49 cards)
4 things hepatocytes do
protein synthesis,
bile acid production
xenobiotic metabolism
vitamin D activation
what do endothelial cells do?
secret endothelia, prostaglandin, nitric oxide and interlukins
what do kupfter cells do?
macrophages
- sit on the endothelium ( sinusoid) - clear endotoxinsy
- act on antigen presenting cells
- secrete cytokines
what do stellate cells do?
store Vit A and fat,
produce collagen IV AKA reticulin)
produce hepatic growth factor
what type of cells are in the bile duct?
cuboidal and columnar for IgA and IgM production
list 6 clinical signs of alcoholic liver disease….
palmar erythema, duprytrons contracture, caput medusae, spider nevi, ascites, jaundice.
what is alcoholic steatosis?
fatty infiltrate o he liver secondarry to alcohol use.
what is chronic hepatitis?
when the pericentral area become fibrosed. other indications are thickened septa and nodule formations.
Name 6 complications of Chronic Liver Disease?
Portal hypertension, spontaneous bacterial peritonitis, acute decompensation ( hepatic encephalopathy/coagulopathy), hepato-renal syndrome, hepatocellular carcinoma.
how do you treat alcohol withdrawal?
benzodiazepines - they act in similar way to alcohol and you can tirade the dose down.
Vit B supplement.
What is Wernicke’s Encephalopathy?
acute neuro symptoms due to thiamine deficiency. common in alcohol withdrawal.
3 symptoms of Wernicke’s Encephalopathy?
Encephalopathy
Occulomotor disturbance
Gait ataxia
What is Korsakoff’s syndrome?
irreversible dementia with confabulation due to maxillary body damage.
A 750ml bottle of 12% wine has how many units in it?
9 ( 1 unit is 10ml of pure alcohol)
A 4% 1/2pint of beer has how many units?
1/2 pint = 284ml 4% of this is 11.36ml ( 1 unit = 10ml of pure alcohol)
whats in the portal tract?
a bile duct, a hepatic artery and a portal vein.
which cells surround the portal tract?
the peri-portal zone
which cells surround the central vein?
the centre-lobular zone
what are the ‘limiting plate’?
tightly bound hepatocytes surrounding each portal tract.
what is a histological indicator of chronic liver disease?
inflammation and eroding of the limiting plate.
the pockets of endothelial cells surrounding the hepatocytes are called?
sinusoids
what can be found in the ‘Space of Disse’
reticulin fibres and stellate cells
reticulin if made of what?
collagen type III
what is haemochromatosis?
gene mutation - trap iron.
