Pharmacy

Question 1

Acidic drugs require an acidic environment to be absorbed, and basic drugs require a basic environment to be absorbed. True/False?

Answer 1

True

Question 2

Give 3 examples of acidic drugs

Answer 2

Penicillin
Aspirin
Phenytoin

Question 3

Give 3 examples of basic drugs

Answer 3

Diazepam
Morphine
Pethidine

Question 4

What will the absorption of penicillin be like if you take a PPI at the same time?

Answer 4

PPI remove HCl from stomach, so less acidic environment, so penicillin won’t absorb as well

Question 5

Which carrier protein binds acidic drugs?

Answer 5

Albumin

Question 6

Which carrier protein binds basic drugs?

Answer 6

Alpha-1 acid glycoprotein (A1AG)

Question 7

In the elderly, which carrier protein is higher in abundance - albumin or A1AG?

Answer 7

A1AG

Relative low albumin concn

Question 8

Vd is a theoretical volume describing if all drug was absorbed into blood. The bigger the Vd, the more/less lipid soluble it is.

Answer 8

Vd is a theoretical volume describing if all drug was absorbed into blood. The bigger the Vd, the more lipid soluble it is.

Question 9

What effect does a large Vd have on half-life of a drug?

Answer 9

Half-life of drug increases (big Vd means drug is sitting in adipose tissue)

Question 10

Give the equation for calculating the therapeutic index of a drug

Answer 10

LD50/ED50

lethal dose50)/(effective dose50

Question 11

List some drugs that have a narrow therapeutic index

Answer 11

Warfarin
Theophylline
Levothyroxine
Digoxin
Lithium
Vancomycin
Gentamicin