Pharmacology - Psychiatry Flashcards

1
Q

How do monamine oxidase inhibitors work? Give an example of one

A

Slow down breakdown of neurotransmitters by inhibiting MAO enzyme
Phenelzine

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2
Q

List some TCA’s

A

Amitriptyline
Clomipramine
Imipramine
Dosulepin

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3
Q

List some SSRI’s

A

Fluoxetine
Paroxetine
Citalopram
Sertraline

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4
Q

Whereabouts in the synapse do MAO inhibitors act?

A

Presynaptic terminal

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5
Q

Whereabouts in the synapse do TCA’s act?

A

Synaptic cleft

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6
Q

Whereabouts in the synapse do SSRI’s act?

A

Presynaptic terminal

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7
Q

Which SSRI’s can inhibit CYP450 system?

A

Fluoxetine

Paroxetine

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8
Q

List some adverse effects of SSRI’s

A

Sexual dysfunction
GI disturbance
Short-term anxiety

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9
Q

List some adverse effects of TCA’s

A

Constipation
Dry mouth
Blurred vision
Postural hypotension

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10
Q

Which class of drug are major tranquilizers - antipsychotics or benzodiazepines?

A

Antipsychotics

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11
Q

What is the general overall mechanism of benzodiazepines?

A

Act at GABA receptor mediate its inhibitory effect

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12
Q

List the pharmacological clinical effects of benzodiazepines

A

Reduce anxiety and aggression
Hypnosis, sedation
Muscle relaxation
Anticonvulsant effect

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13
Q

Which BZD acts as a GABA receptor antagonist and what is its effect on anxiety?

A

Flumazenil

Increases anxiety

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14
Q

Some people can develop tolerance to BZD’s - what is the significance of this?

A

The doses that work for them can be lethal in normal people

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15
Q

List the clinical effects of rapid withdrawal of BZD’s

A

Confusion, psychosis
Insomnia
Anxiety
Appetite + weight loss

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