Organ Transplant Flashcards
criteria for organ transplant
presence of end stage disease
failure of conventional therapy
absence of untreatable malignancy or irreversible infection
absence of disease that would attack the transplanted organ
where do organs come from
cadaveric donors
living donors
factors considered in decision to allocate an organ
ABO blood typing tissue size waiting time severity of illness geographic locations
3 gen complications following organ transplant surgery
transplant rejection
infection
surgical prblms
3 drug approach to post transplant management
induction immunosuppression
maintenance immunosuppressive
anti rejection immunosuppressive
PT considerations for transplant drugs
increased risk of infection
serious AEs
hyperacute rejection
48 hrs non functional
ABO or human leukocyte antigen blood type
unresponsive to Tx
acute rejection
3-12 months
adaptive response involving T cells
verifying ABO and crossmatching decreases likelihood
HLA matching sign improves success rate
chronic rejection
most likely antibody mediated - T and B
manifests differently in each organ
S/s of organ transplant infection/rejection
●Temperature greater than 38° C (100.5° F) ●Fatigue ●Shaking, chills, body aches ●Sweating ●Diarrhea lasting longer than 2 days ●Dyspnea ●Cough or sore throat
graft vs host disease
GvHD is the donors immune cells causing recipient organ rejection
Transplant Rejection is when the recipient immune response rejects the
Actue GvHD vs Chronic
acute - cytokine storm
chronic - multiple organ tox
PT considerations for post op transplant
extreme weakness - liver
decreased O2 for heart and lung
deconditioned
suitable OM for organ transplant gen
mobility balance endurance pain gait
heart viable
4-6hrs
