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Year 5 path SW COPY > Histopathlogy 5: Connective Tissue Disorders > Flashcards

Histopathlogy 5: Connective Tissue Disorders Flashcards

1
Q

List 3 auto-antibodies seen in SLE ?

A

Anti-dsDNA
Anti-Smith
Anti-histone (drug related)

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2
Q

What type of hypersensitivity reaction is seen in SLE ?

A

Type 3 hypersensitivity reaction

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3
Q

What is the HLA association with SLE ?

A

HLA DR3

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4
Q

Name the heart condition that can be caused by SLE ?

A

Libman-sack endocarditis

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5
Q

List the signs and symptoms of SLE using the mnemonic SOAP BRAIN MD

A

Serositis
Oral ulcers
Arthritis
Photosensitivity

Blood disorders- AIHA, ITP 
Renal involvement - Type 2 RPGN 
ANA +ve
Immune- anti-dsDNA, anti-smith
Neuro symptoms
Malar rash
Discoid rash
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6
Q

Which auto antibodies are seen in Diffuse scleroderma ?

A

Anti-scl70

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7
Q

Which autoantibodies are seen in limited scleroderma (CREST) ?

A

Anti-centromere

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8
Q

Which HLA is associated with scleroderma ?

A

HLA DR5

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9
Q

List the signs and symptoms of limited scleroderma (CREST) ?

A 
Calcinosis
Raynauds
Esophageal dysmotility 
Sclerodactily 
Telangiectasia

No involvement of the trunk

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10
Q

In scleroderma there is increased ……… deposition in the skin causing tight skin

A

Collagen

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11
Q

Which autoantibodies are seen in Polymyositis and dermatomyositis ?

A

anti- Jo1

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12
Q

Patient has proximal muscle weakness. Their bloods show increased CK and abnormal EMG. No rash is seen.

Most likely diagnosis?

A

Polymyositis

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13
Q

Patient has proximal muscle weakness. Their bloods show increased CK and abnormal EMG. A heliotrope rash is seen on the eyelids. There are Gottron papules on the knuckles

Most likely diagnosis?

A

Dermatomyositis

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14
Q

Japanese lady with absence of pulse and Claudication.

The Rheumatologist says that its a large vessel arthritis.

Most likely diagnosis ?

A

Takayasu’s arteritis

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15
Q

Elderly man presents with a temporal headache, jaw claudication and scalp tenderness.

Most likely diagnosis?

A

Temporal arteritis

Large vessel vasculitis

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16
Q

A man presents with abdo pain and signs of renal impairment. Angiogram shows “rosary beads” because of multiple aneurysms.

Most likely diagnosis?
Associated with which disease?

A 
Polyartheritis nodosa (medium vessel arteritis)
Hepatitis B
17
Q

List the diagnostic features of Kawasaki disease?

A 
Fever >5 days 
Erythematous Rash on palms and soles
Non purulent conjunctivitis
Cervical lymohadenopathy 
Coronary artery aneurysms 
Mucous membrane involvement (strawberry tongue, cracked lips)
18
Q

A heavy smoker with ulceration of the toes and fingers has an angiogram which shows a “corkscrew appearance”.

Most likely diagnosis?

A

Buerger’s disease

19
Q

List the triad of features seen in Polyangitis with granulomatosis ?

A

Saddle nose
Pulmonary haemorrhage
Glomerulonephritis (Crescentic)

20
Q

Which ANCA is associated with polyangitis with granulomatosis (Wagner’s) ?

A

C-ANCA

21
Q

List 3 characteristic features of Eosinophilic granulomatosis with polyangitis (Churg-Strauss syndrome) ?

A

Asthma
Eosinophilia
P-ANCA vasculitis

22
Q

List 3 features of Microscopic polyangitis?

A

Pulmonary haemorrhage (haemoptysis)
Glomerulonephritis (Pauci immune RPGN)
P-ANCA small vessel vasculitis

23
Q

Which type of amyloidosis is seen in multiple myeloma ?

A

AL amyloidosis (primary)

With free light chains, monoclonal Ig and Bence jones proteins in the urine

24
Q

List some causes of AA amyloidosis?

A

Rheumatoid arthritis
Chronic TB infection
IBD
Hodgkin’s lymphoma

25
Q

In amyloidosis associated with haemodialysis you get ………… deposition ?

A

Beta 2 microglobulin deposition

26
Q

Name one familial amyloidosis ?

A

Familial Mediterranean fever

27
Q

Congo red staining shows ……………. under polarised light if there is Amyloidosis

A

apple green birefringence

28
Q

An Afro Caribbean patient presents with SOB and cough. Examination shows erythema nodosum, lymphadenopathy and hepatosplenomegaly. X-ray shows bilateral hilar lymphadenopathy
Histology shows: non-caseating granulomas

Most likely diagnosis?

A

Sarcoidosis

29
Q

Which electrolyte is often elevated in Sarcoidosis?

A

Ca2+

Year 5 path SW COPY (106 decks)

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