Haem 18: Haem quiz

Question 1

Features of anaemia of chronic disease

Answer 1

reduced RBC life span
cytokine release - IFN gamma, IL1, TNF
inflammatory markers
iron and transferring reduced

Question 2

features of hodgkin lymphoma

Answer 2

peak adolescence and >50
painless supra-diaphragmatic lymphadenopathy
1/3 have B symptoms - fever, ns, wt loss (>10% in 6 months)
HLA DPB1 associations

Question 3

normal range for Hb

Answer 3

M = 130-180 g/L

F = 115 - 165 g/L

Question 4

normal range for WCC

Answer 4

4 - 11 x 10^9/l

Question 5

normal range for platelets

Answer 5

150 - 450 x 10^9/l

Question 6

normal range for MCV

Answer 6

80-100 fl

Question 7

3 general signs of anaemia

Answer 7

pale mucous membranes
tachycardia
cardiomegaly/ CCF

Question 8

3 specific signs of anamia

Answer 8

koilonychia
glossitis - b12 def
jaundice - haemolysis

Question 9

causes of anaemia with low MCV

Answer 9

iron def
thalassaemia
ACD

Question 10

when are reticulocytes present

Answer 10

haemolysis
haemorrhage
haematinics

Question 11

when are reticulocytes absent

Answer 11

inadequate haematinics
BM failure
acute major haemorrhage (r response takes > 6hrs)

Question 12

features of blood film in iron deficiency anaemia

Answer 12

pencil cells
anisocytosis
poikilocytosis
hypochromic

Question 13

2 most common sources of bleeding in IDA

Answer 13

uterine (menstrual/pregnancies)

gastrointestinal

Question 14

causes of pancytopaenia

Answer 14

aplastic anaemia 
leukaemia
infiltration 
drugs - chemo 
b12/folate deficiency

Question 15

AML blood film

Answer 15

granular myeloid blasts with auer rods

Question 16

causes of thrombocytopaenia

Answer 16

defect in platelet production:

• drugs - chemo, thiazides
• bm disorders

increased destruction of platelets:

• ITP
• DIC
• heparin-induced thrombocytopenia