Peripheral Neuropathy

Question 1

Drug Causes of Peripheral Neuropathy (5).

Answer 1

MAVIN :

1. Metronidazole.
2. Amiodarone.
3. Vincristine.
4. Isoniazid.
5. Nitrofurantoin.

Question 2

Aetiology of Peripheral Neuropathy with Predominant Motor Loss (6).

Answer 2

1. GBS.
2. Acute Intermittent Porphyria.
3. Lead Poisoning.
4. Charcot-Marie-Tooth.
5. CIDP (Chronic Inflammatory Demyelinating Polyneuropathy).
6. Diphtheria.

Question 3

Which of the above causes presents with a combination of abdominal pain and neurological signs?

Answer 3

1. Acute Intermittent Porphyria.

2. Lead Poisoning.

Question 4

Clinical Features of Lead Poisoning (5).

Answer 4

1. Abdominal Pain.
2. Motor Peripheral Neuropathy.
3. Fatigue.
4. Constipation.
5. Blue Lines on Gum Margin.

Question 5

Investigations of Lead Poisoning (

Answer 5

1. Diagnosis : High Lead Level.
2. FBC : Microcytic Anaemia.
3. Blood Film : Basophilic Stippling and Clover-Leaf.
4. Similar to Acute Intermittent Porphyria : Raised Serum and Urine Delta Aminolavelunic Acid.

Question 6

Management of Lead Poisoning (4).

Answer 6

Chelating Agents e.g. :-

1. DMSA - Dimercaptosuccinic Acid.
2. D-Penicillamine.
3. EDTA.
4. Dimercaprol.

Question 7

Aetiology of Peripheral Neuropathy with Predominant Sensory Loss (5C).

Answer 7

ABCDE :
A. Alcoholism.
B. B12/Folate Deficiency.
C. Chronic Kidney Disease.
D. Diabetes.
E. Everything Else e.g. Vasculitis, Paraneoplastic.

• . Uraemia.
• . Leprosy.
• . Amyloidosis.

Question 8

Aetiology of Alcoholic Neuropathy.

Answer 8

Secondary to both direct toxic effects and reduced absorption of B Vitamins.

Question 9

Clinical Features of SCDSC.

Answer 9

1. Dorsal Column Usually Affected First and then Distal Paraesthesia.
2. UMN Signs in Legs e.g. Extensor Plantars, Brisk Knee Reflexes, Absent Ankle Jerks.

Question 10

Clinical Presentation of Peripheral Neuropathy with Predominant Sensory Problems.

Answer 10

Length Dependent - Glove-and-Stocking Distribution.