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402: Rheum and derm > Therapeutics > Flashcards

Therapeutics Flashcards

1
Q

Adverse effects of methotrexate [5]

A

Teratogenic

Liver toxicity

Bone marrow suppression

Mucositis

Pulmonary fibrosis

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2
Q

What DMARD is associated with hepatotoxicity, mucositis, pulmonary fibrosis and bone marrow suppression?

A

Methotrexate

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3
Q

Mechanism of methotrexate

A

Disrupts folate metabolism

- Leads to inhibited nucleotide synthesis= Impaired DNA formation

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4
Q

What drug is an anti-CD20 monoclonal antibody?

A

Rituximab

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5
Q

What drug acts mimics the inhibitor effects of soluble TNF receptors

A

Etanercept

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6
Q

Infliximab is a ________ that works by _________

A

Chimeric monoclonal antibody- neutralises TNF-alpha

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7
Q

Adalimumab is a _______ that works by __________

A

Monoclonal antibody- neutralises TNF alpha

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7
Q

Adalimumab is a _______ that works by __________

A

Monoclonal antibody- neutralises TNF alpha

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8
Q

Anti-TNF agents have a high risk of _______

A

Reactivating TB and Hep B infections

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9
Q

Adverse effects of rituximab [5]

A

Increased risk of infections

Peripheral neuropathy

Thrombocytopenia

Night sweats

Pulmonary/ liver toxicity

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10
Q

What biological agent has increased risk of infections, pulmonary toxicity, peripheral neuropathy and night sweats.

A

Rituximab

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11
Q

Short-term side effects of glucocorticoids

A

Insomnia

Hypertension

Tachycardia

Hyperglycaemia

Dyslipidaemia

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12
Q

Long-term side effects of glucocorticoids [8]

A

Cushing’s syndrome

Metabolic syndrome

Skin changes: striae

Osteoporosis

Peptic ulcers

Poor wound healing

Glaucoma, cataracts

Proximal myopathy.

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13
Q

Bisphosphonates are analogues of ________ which _________

A

Pyrophosphates - inhibit osteoclast activity

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14
Q

Indications of bisphosphonates

A

Osteoporosis

Hypercalcaemia

Paget’s disease

Bone metastasis

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15
Q

Examples of bisphosphonates

A

Alendronate

Risedronate

Zolendronate

16
Q

Adverse effects of bisphosphonates [5]

A

Dyspepsia

Oesophagitis/ Oesophageal ulcers

Vitamin D deficiency/ hypocalcaemia

Osteonecrosis of the jaw

Atypical stress facture of the proximal femoral shaft (alendronate)

17
Q

Men and women should wait ________ before trying to conceive after stopping methotrexate

A

6 months

18
Q

Examples of moderate topical steroids

A

Clobetasone butyrate (Eumovate)

19
Q

Example of potent topical steroid

A

Betamethasone (Betnovate)

402: Rheum and derm (12 decks)

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