M4: L-8 Flashcards

1
Q

Why is peptide hydrolysis difficult?

A
  • It is an unreactive acid derivative

- water is a poor nucleophile

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2
Q

What is the name of enzymes used to enable efficient hydrolysis of peptide bonds?

A

Proteases

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3
Q

What does chymotrypsin do?

A

Breaks peptide bones on carbonyl side of aromatic amino acids

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4
Q

What does carboxypeptidase do?

A

Breaks peptide bones to remove the C terminal amino acid. ( is a metalloenzyme containing zinc ion which is important to reaction)

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