M4: L-7 Flashcards
1
Q
By convention when we draw joint amino acids which side does the unreacted amine group go as opposed to the unreacted acid group
A
Left
2
Q
Why are amino acids joint with peptide bonds unreactive towards nucleophiles, planar, and rigid
A
Resonance structure of the peptide bond ( C=O shares second bond electron with C—N so sometimes that bond is C=N)
3
Q
What is < 75 amino acids called?
A
Polypeptide chain
4
Q
What is < 75 amino acids called?
A
Protein
5
Q
What drives the secondary/ quaternary structures?
A
- hydrogen bonding
- disulfide bond formation
- desire for hydrophobic amino acids on inside
6
Q
What do we use to protect an amine group?
A
BOC group
7
Q
How is a BOC group removed?
A
With acid
8
Q
What is used to protect a Carboxylic acid group in peptide synthesis?
A
OMe group
9
Q
What is used to remove an OMe protecting group
A
Base
10
Q
What is used to catalyse peptide formation?
A
DCC
