M4: L-8 Flashcards
1
Q
Why is peptide hydrolysis difficult?
A
- It is an unreactive acid derivative
- water is a poor nucleophile
2
Q
What is the name of enzymes used to enable efficient hydrolysis of peptide bonds?
A
Proteases
3
Q
What does chymotrypsin do?
A
Breaks peptide bones on carbonyl side of aromatic amino acids
4
Q
What does carboxypeptidase do?
A
Breaks peptide bones to remove the C terminal amino acid. ( is a metalloenzyme containing zinc ion which is important to reaction)
