M3: L-8

Question 1

For what substitution reaction mechanism is a good leaving group more important?

Answer 1

SN1

Question 2

What conditions are used to create better leaving groups from OH and OR electrophiles?

Answer 2

acidic conditions ( pronation)

Question 3

For which substitution reaction mechanism is having a nucleophile more important?

Answer 3

SN2

Question 4

What are the ideal solvent conditions for SN1 reaction mechanisms?

Answer 4

• polar

- able to H bond

Question 5

What are the ideal solvent conditions for SN2 reaction mechanisms?

Answer 5

• Not able to H bond

Question 6

What determines which elimination reaction mechanism occurs?

Answer 6

Base strength ( strong base = E2) (weak base = E1)

Question 7

Explain the E1 reaction mechanism:

Answer 7

1. Electrophile leaves and generates a carbocation intermediate
2. A base (H20 most abundant) removes H+ to form C=C

Question 8

What controls the ratio of E1: SN1 reactions occurring

Answer 8

Relative rates of the two alternative fast steps

Question 9

Explain the E2 reaction mechanism:

Answer 9

The electrophile leaves at the same time the base takes the H+