IS xx Flashcards
A 10-month-old girl presented with fever of 39°C and with diarrhea. Stool was (+) for fecal leukocytes. Her history was
remarkable for recurrent bronchitis, pneumonia, and enterocolitis. Her serum IgA level is 15 mg/dL (normal is 50 mg/dL). What is the role of IgA? * 1/1
opsonization
release of antihelminthic enzymes by eosinophils
activation of the classical complement pathway
inhibition of microbial adhesion
inhibition of microbial adhesion
A 34-year old woman awoke from a nap in her mobile home at the smell of gas. She went to the kitchen and it her propane stove, causing an explosion. She sustained severe burns over most of her body surface. She managed to get out to be pulled away from the trailer by her neighbor. by the time the paramedics arrived, she was in extreme pain and had the following vital signs: pulse 120
beats/min, blood pressure 110/60 mm Hg, respiratory rate 25/min, and temperature 36.8°C. She received IV fluids, an intravenous bolus of morphine sulfate, and oxygen mask. What was disrupted most significantly in this patient?
first line of defense
second line of defense
phagocytosis
Ab production
first line of defense
A 14-year old girl was referred to radiology because of abdominal pain and vague respiratory symptoms. An abdominal x-ray with barium swallow revealed an approximately 20-cm long train track-line filling defect. The patient’s stool was (+) for ova of a common parasite. Chest x-ray interferon-gamma - mediated killing of phagocytosed pathogen by natural killer showed pulmonary infiltrates. what is the likely to be elevated in this patient?
basophils neutrophils platelets eosinophils lymphocytes
eosinophils
A 25-year old woman in the 32nd week of gestation develops sepsis and gives birth to a stillborn infant. She lives on a farm, where she milks cows and often she drinks unpasteurized milk. An
intracellular bacterium, Listeria monocytogenes is recovered from the mother’s blood and all of the autopsy samples obtained from the infant. What is important in the early control of L. monocytogenes infection?
cells
Ab-mediated killing of L. monocytogenes
eosinophilic infiltration
granuloma formation
A 20-year old woman injured in a car accident while driving without a seat belt fastened is brought to the ER department. Internal bleeding is suspected, and an emergency laparotomy is performed, which reveals a ruptured spleen necessitating splenectomy. The patient is at risk for developing:
B cell immunodeficiency T cell immunodeficiency HIV/AIDS infections with encapsulated organisms malabsorption
infections with encapsulated organisms
A researcher working in Immunology has developed an antibody that reacts with a protein that is expressed on developing immune cells. if the researcher decides to stain various lymphoid tissues to look for expression of this protein using the Ab that he developed, what tissue would most likely give a strong reaction? 1/1 tonsils spleen lymph nodes Peyer's patches thymus
thymus
Ag-presentation is an important aspect of immune function. Several cell types are capable of presenting the Ag to immune cells. What cell type is least likely to be called as a professional Ag presenting cell? 1/1 B lymphocyte T lymphocyte macrophage dendritic cell Langerhans cells
T lymphocyte
A 40-year old man was treated for an upper respiratory tract infection with an antibiotic. After administration of the drug, the patient developed fever, pruritus, and rashes. A complete blood count was done. Apart from the anemia and mild lymphocytosis, the rest of the complete blood count was within normal limits. Direct Coombs' test was positive. The most likely reason for the autoimmune hemolytic anemia after therapy in this patient was due to the drug being a: 1/1 superantigen hapten polysaccharide Ag mitogen ionophore
hapten
A 16-year old boy is injured while
playing football. He does not remember
the last time he had a tetanus shot, so the
attending physician administers a tetanus
toxoid vaccine. this kind of immunity
would be best classified as:
natural active natural passive artificial active artificial passive acquired passive
active artificial
A child with recurrent pyogenic
sinopulmonary infections comes to the
clinic with fever and sinusitis. on workup
of this patient, it is discovered that the
neutrophils of the child do not show the
oxidative burst phenomenon. A
diagnosis of chronic granulomatous
disease is made. Because neutrophils are
part of the innate immune response, the
characteristic that most likely
corresponds to cells of the innate
immune system is:
1/1
memory response
specificity lag time for primary response
present at birth
acquired response to Ags
present at birth
A child with recurrent pyogenic
sinopulmonary infections comes to the
clinic with fever and sinusitis. on workup
of this patient, it is discovered that the
neutrophils of the child do not show the
oxidative burst phenomenon. A
diagnosis of chronic granulomatous
disease is made. Because neutrophils are
part of the innate immune response, the
characteristic that most likely
corresponds to cells of the innate
immune system is:
1/1
memory response
specificity lag time for primary response
present at birth
acquired response to Ags
present at birth
Digestion of an Ig with pepsin yields F(ab’)2 fragments. Several clinical trials using F(ab’)2 are being conducted for their use as blocking molecules. What is the immune phenomenon that is most likely to be seen with an F(ab’)2 fragment?
1/1
complement fixation
opsonization
Ag neutralization
Ig polymerization react with the Fc receptor
Ag neutralization
Which type of cells is known to be involved in the initial presentation of antigen to T lymphocytes? 1/1 A Dendritic cells B Plasma cells C Neutrophil polymorphonuclear leucocytes D Erythrocytes E Platelets
A Dendritic cells
Which of the following cells are thought NOT to be of monocyte-macrophage lineage? 1/1 A Neutrophils B Follicular dendritic cells of lymph nodes C Kupffer cells in liver D Histiocytes in tissues E Monocytes in blood
A Neutrophils
Which of the following types of cell produce IgE? 1/1 A Mast cells B Eosinophils C Basophils D T lymphocytes E Plasma cells
E Plasma cells
Helper CD4+ T lymphocytes recognize which one of the following types of molecules on dendritic cells? 1/1 A HLA class I antigen B HLA class III antigen C Processed peptides from antigen D CD8 antigen E Surface immunoglobulin
C Processed peptides from antigen
Which one of the following statements
about the alternate pathway is FALSE?
1/1
A Properdin forms part of the C5 convertase.
B The alternate pathway isphylogenetically older than the classical pathway.
C The alternate pathway can be activated by bacterial cell walls.
D There is a positive feedback loop.
E Activity in vivo is best estimated by C4 levels.
E Activity in vivo is best estimated by C4 levels.
Which of the following cell types is phagocytic? 1/1 A Hepatocytes B Lymphocytes C Monocytes D Erythrocytes E Plasma cells
C Monocytes
Type I hypersensitivity classically involves which one of the following? 1/1 A IgM B IgD C Macrophages D IgE E Enterocytes
D IgE
Which one of the following cytokines act as a chemo-attractant for eosinophils: 1/1 A IL-5 B IL-10 C IFN-gamma D IL-2 E IL-7
A IL-5
Which one of the following statements about isotype switching by B cells is true? 1/1 A Isotype switching by B cells is dependent on the interaction between CD40 on the Bcell surface and its ligand on activated T cells, CD40L.
B B-cell switching involves switching from IgG to IgM isotypes
C Specific recognition of the antigenic peptide is not required D CD28 on the B cell recognizes CD86 on the T cell to allow augmentation of the activation process
A Isotype switching by B cells is dependent on the interaction between CD40 on the Bcell surface and its ligand on activated T cells, CD40L.
When either CD40 or CD40 ligand are
missing (as in CD40 Ligand or CD40
deficiency), no switching occurs. Which
one of the following statements about
antibody production is true?
1/1
A B cells cannot produce specific antibody without T-cell help.
B Tregs can produce antibodies to regulate autoantibody production
C The BCR of B cells is a member of the immunoglobulin superfamily
C The BCR of B cells is a member of the immunoglobulin superfamily
Which one of the following statements about genes for immunoglobulin production is true?
1/1
A Heavy and light chains of immunoglobulin molecules are coded for by genes on the same chromosome
B Kappa chains are coded on chromosome 14
C Lambda chains are coded on chromosome 14
D Heavy chains are coded on chromosome 14
D Heavy chains are coded on chromosome 14
Where do B lymphocytes develop? 1/1 spleen thymus MALT tonsils none of the choices
none of the choices
What is the normal CD4: CD8 ratio? 1/1 10:1 2:1 5:1 4:2
2:1
Which of the following is false?
1/1
The anamnestic response is an accelerated response.
IgM is produced first in a primary response.
IgG is the predominant Ab in the secondary response.
the primary and the secondary response are similar
the primary and the secondary response are similar
Which part of the immunoglobulin molecule determines the Ig class? 1/1 light chains heavy chains Fc Fab none of the choice
heavy chains
Injection of an attenuated Ag should result in the development of which type of immunity? 1/1 active passive innate
active
An Ab-mediated immunity involving B lymphocytes and plasma cells and provides defenses against extracellular pathogens.
cell mediated
humoral
innate
T lymphocyte-mediated immunity
humoral
Are the sites of Ag independent differentiation of lymphocytes. 1/1 peripheral lymphoid organs primary lymphoid tissues GALT spleen lymph nodes
primary lymphoid tissues
What is the name of the region of the Ig molecule that creates the Ag-binding site? 1/1 Fc CH region CV region Fab CL region
Fab (fragment Ag-binding)
Which Ig is a pentamer and is the first immunoglobulin developed during human fetal development at 20 weeks? 1/1 IgM IgG IgA IgD IgE
IgM
Which Ig is present on mucosal surfacesand serves as the first line of defense against Ags? 1/1 IgG IgM IgD IgE IgA
IgA
Which of these Ab can bind to complement?
IgA and IgE
IgG and IgM
IgG and IgM
Where does the complement attach to the Ig molecule? 1/1 IgG and IgD IgG and IgA to the TCR to the BCR to the Fab region to the Fc region none of the choices
to the Fc region
Which cells have surface receptors to the Fc portion of IgE? 1/1 neutrophils and basophils basophils and macrophages mast cells and basophils eosinophils and neutrophils
mast cells and basophils
Which ions are required in the complement cascade? 1/1 chromium (III) Cr3+ and hydrogen H+ calcium Ca2+ and magnesium Mg2+ potassium K+ and aluminum Al3+ cadmium Cd2+ and iron (II) Fe2+ none of the choices
calcium Ca2+ and magnesium Mg2+
What is the end point of complement activation?
opsonization chemotaxis phagocytosis cellular lysis none of the choice
cellular lysis
Are cytokines produced by T cells and other cells that inhibit viral synthesis or act as immune regulators 1/1 interferons interleukins TGF beta
interferons
Which cells do not possess HLA Ags? 1/1 neutrophils chemokines TNF alpha macrophages erythrocytes megakaryocytes hepatocytes melanocytes
erythrocytes
The chemokine receptors \_\_\_\_ and \_\_\_\_ function as coreceptors for HIV-1 entry into CD4+ cells. 1/1 CCR6 and CXCR 8 CXCR4 and CCR5 C1 AND CXC10 CX3C and XC4
CXCR4 and CCR5
The chemokine receptors CXCR4 and CCR5 function as coreceptors for HIV-1 entry into CD4+ cells. During the early stages of HIV infection, viral isolates tend to use CCR5 for viral entry, while later isolates tend to use CXCR4. B lymphocytes and T lymphocytes are derived from
A. Hematopoietic stem cells
B. Macrophages or monocytes
C. Mucosa-associated lymphoid tissue D.
The fetal liver
A. Hematopoietic stem cells
