Flashcards in 12. Association Analysis Deck (4):
What is genetic association?
Genetic Association is the presence of a variant allele at a higher frequency in unrelated subjects with a particular disease (cases), compared to those that do not have the disease (controls).
What is a loci and a haplotype?
• Locus - A position in the genome
• Haplotype - This is the order of alleles along achromosome
What are cases?
Cases are subjects with the disease of interest, e.g. obesity, schizophrenia, hypertension