Path 9: Cellular events in chronic inflammation

Question 1

Transudate

Answer 1

a classification of fluid

going to push fluid out of cells

Question 2

Exudate

Answer 2

fluid and protein leakage

PUS

Question 3

Retraction of endothelial cells

Answer 3

Transudate

Question 4

Rabbit - Liver

Answer 4

Multifocal-disimminated

Raised nodules (something being added)
-made by bile ducts

Hypertrophy/hyperplasia

Cholongitis
-parasite eimeria stiadae (shed in feces) coccidia

Question 5

What are 3 possibilities outcomes of Acute inflammation?

Answer 5

Complete resolution
-restoration of the site of inflammation to normal
-outcome if injury short-lived or little tissue destruction occurs

Healing by connective tissue replacement (fibrosis)
-substantial tissue destruction
-tissues can NOT regenerate
-abundant fibrin exudation that can NOT be cleared

Progression to chronic inflammation
-if there is persistence of injurious agent or interference with normal healing

Question 6

What are the events in the resolution of inflammation?

Answer 6

The big players are:

Macrophage

Necrotic tissue

Question 7

What is the difference of Fibrin and fibrous?

Answer 7

Fibrin= protein (acute inflammation)

Fibrous= collagen (chronic inflammation)

Question 8

Outcomes of acute inflammation: including resolution, healing by fibrosis, or chronic inflammation

Answer 8

Question 9

Morphologic patterns of acute inflammation are?

Answer 9

Serous inflammation

Fibrinous inflammation

Suppurative inflammation

Ulcers

Question 10

Describe Serous inflammation?

Answer 10

This, watery fluid derived from plasma or mesothelial cells
-Mesothelial cells line the peritoneum, pleura, and pericardium
-fluid in there 3 cavities is called EFFUSION

Question 11

Describe Fibrinous inflammation?

Answer 11

Characterized by accumulation of FIBRIN
-fibrinogen leaves blood vessel and is converted to fibrin

Large vascular leaks or procoagulant stimulus

Characteristic of inflammation in body cavity lining

If fibrin NOT removed, can stimulate proliferation of fibroblasts and vessels and lead to scarring (FIBROSIS)

Question 12

Goat - lung

Answer 12

Purple lung is consolidated
-when its full of exudate
-white is fibrin

Broncho pneumonia with fibronousitis

Ex. Fibrinous inflammation (acute)

Question 13

Suppurative/Purulent inflammation description?

Answer 13

Characterized by production of PUS/PURULENT EXUDATE
-neutrophils, liquefactive necrosis, edema

Pyogenic bacteria (ex. staphylococcus) produce pus

Abscess: localized collection of purulent inflammation

Question 14

What is and example of Suppurative/Purulent inflammation?

Answer 14

Suppurative Mastitis

mostly pus

Question 15

Describe Ulcers?

Answer 15

Local defect or excavation of the surface of organ or tissue
-Mucosa of GI tract, genitourinary tract
-skin/subcutis

Question 16

What is the difference between Erosion vs ulcer?

Answer 16

Erosion: more superficial NOT below the basement membrane

Ulcer: It is a lot deeper than erosion there is a crater from mucosa to submucosa

Question 17

An example is of an ulcer - Calf

Answer 17

Proliferated ulcer

around it dull and granule

histology will have a crater

Question 18

Pig abdominal cavity

Answer 18

White slightly yellow

Partially translucent

Fibrinous Peritonitis

Question 19

Fibrin pleural cavity

Answer 19

Multifocal

Question 20

Pericardium

Answer 20

Fibrinous percarditis

Polyserositis

Glaesersas (bacterial infection)

Question 21

Shell out of pericardium shows heart

Answer 21

Fibrin

smooth