Skeletal system Flashcards

1
Q

Major functions of the skeletal systems;

A
  • support
  • protection
  • assistance in movement (muscles, power, tendons connect)
  • mineral storage and release (blood/boje Calsium and Phosphorous levels maintained)
  • blood cell production (red marrow present in certain use haematopoesis to produce RBCs, white cells, platelets)
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2
Q

Axial

A

Axial = along the axis
~80 Bones

Essentially houses the vital parts of the body

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3
Q

Appendicular

A

Appendicular = appendage
~126 Bones

  • locomotion

Cartilage – protects joints,
Tendons – connects muscles to bone
Ligaments – connects bones to bones

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4
Q

The skeletal system

A

Bones

Associated connective tissues; include cartilage, tendons and ligaments

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5
Q

List the types of bones;

A

Sesamoid ( lie within tendons)
Short bones
Flat bones
Long bones
Irregular bones

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6
Q

Functions of Bones

A

support and articulation

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7
Q

Structure of different bones

A

Vary in proportions of:
Compact bone
dense and solid in appearance
Protection and strength
Repeating circular units
osteons

Cancellous (spongy) bone
characterized by open space partially filled with needle-like structures = trabeculae
Strength without weight

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8
Q

Short, flat, and irregular bones&raquo_space;

A

Inner portion = is cancellous /spongy bone

Outer portion = covered on the outside with compact bone

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9
Q

Anatomy of a long bone

A

Diaphysis
Hollow
outside compact bone
Inner - spongy
Support without weight

Epiphyses (plural)
Both ends
Cancellous / spongy

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10
Q

Composition of bone matrix

A

Inorganic salts; Hydroxyapatite :
chemical crystals of Calcium and Phosphate
Compression strength

Organic matrix; Composite of collagen (rope-like) fibres and proteoglycans
Flexible strength

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11
Q

How many cells in a matrix of bones?

A

relatively small number

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12
Q

What is the bone marrow?

A

Specialized type of soft, diffuse connective tissue; called myeloid tissue

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13
Q

Bone marrow - haematopoiesis

A

Site for the production of blood cells

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14
Q

Medullary cavities of Long bone and in spaces of spongy bone= name two types of bone marrow

A

1) Red marrow

2) Yellow marrow

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15
Q

1) Red marrow

A

Found in virtually all bones in an infant’s or child’s body

Produce red blood cells

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16
Q

2) Yellow marrow

A

As an individual ages, red marrow is replaced by yellow marrow

Marrow cells become saturated with fat and are no longer active in blood cell production

17
Q

3 major Major bone cells:

A
  1. Progenitor cells
  2. Osteoblasts
  3. Osteocytes
18
Q
  1. Progenitor cells
A

differentiate into a specific cell type

19
Q
  1. Osteoblasts (giant cells)
A

Bone-forming cells found in all bone surfaces

Ossifiction/osteogenesis

Secretes organic component – collagen

Produce vesicles: release Ca2+ and phosphate ions which contribute to hydroxyapatite formation

Osteoid

20
Q
  1. Osteocytes
A

Differentiated mature non-dividing osteoblasts

Trapped in lacuna and serve mainly as
mechanosensors/ mineral homeostasis

21
Q
  1. Osteocytes - functions and roles
A

Resorb bone through dissolving mineral and breaking down collagen
The “macrophages” of bone
(develop from blood cells called monocytes and macrophages)

22
Q

Explain the process of bone remodelling

A

Removal of existing bone by osteoclasts and the deposition of new bone by osteoblasts

23
Q

What are the results of bone remodelling?

A

growth
changes in bone shape
the adjustment of bone to stress
bone repair
calcium ion regulation in the body fluids

24
Q

How is calcium levels maintained?
[ Skeletal system is a storehouse for 98% of body calcium ]

A

Calcium moves into and out of blood
Bone formation: osteoblasts remove calcium from blood
Bone breakdown: osteoclasts release calcium into blood

25
Q

Calcium homeostasis : hormonal control
What happens to vit D, Calciyomnin, parathyroid hormone LEVELS?

A

Parathyroid hormone (PTH) (increase blood levels)
Vitamin D (increase blood levels)
Calcitonin ( decrease blood levels)

26
Q

Parathyroid hormone (PTH)

A

Primary regulator
Stimulates osteoclasts to breakdown bone matrix
Increases kidney absorption of calcium from urine
= Increases blood calcium levels

27
Q

Vitamin D

A

Increases calcium absorption from the small intestine
= Increases blood calcium levels

28
Q

Calcitonin

A

Hormone produced in the thyroid gland
Stimulates bone deposition by osteoblasts
Inhibits osteoclast activity
decreases blood calcium levels

29
Q

What is the affect of aging skeletol?

A

Decreased collagen makes bones more brittle

Cancellous bone lost first
Decrease in no of trabeculae

Followed by compact (lesser)

Incomplete remodelling

30
Q

Why is the decrease in bone growth slightly more in female?

A

Due to menopause

Loss of the protective effect of oestrogen

(males - reduction in bone mass with age)