2. Glandular cheilitis. Granulomatous cheilitis. Melkersson-Rosenthal syndrome.

Question 1

Glandular Chelitis definition

Answer 1

• Rare chronic inflammatory disorder of minor salivary glands
• Affects lower lip

Question 2

Etiology of Glandular Chelitis

Answer 2

• Unknown
• Implicated factors-chronic irritation, sun exposure, smoking and hereditary

Question 3

Clinical features of Glandular Chelitis

Answer 3

• Swelling of lower lip
• Mucus or mucopustular fluid from ductal openings
• Crustings, erosions and microabscesses

**Lip swelling **sue to hyperplasia or hypertrophy and inflammation of minor salivary glands
Mucopustular fluid caused by pressure on lip due to dilation and pressure of the orifices of minor salivary glands

Question 4

Laboratory tests of Glandular Chelitis

Answer 4

Histopathologic examination

Question 5

Glandular Cheilitis Differential diagnosis

Answer 5

• Granulomatous Cheilitis
• Melkersson–Rosenthal syndrome
• Crohn’s disease
• sarcoidosis
• cystic fibrosis
• lymphangioma

Question 6

Treatment of Glandular Chelitis

Answer 6

• Topical steroids and antibiotics if infected
• Vermilionectomy in severe cases

Question 7

Granulomatous Chelitis Definition

Answer 7

• Rare chronic disorder of lips
• Considered localised form of orofacial granulomatosis or part of chrons disease

Question 8

Granulomatous Chelitis Etiology

Answer 8

• Unknown
• Implicated Dietary or other allergens

Question 9

Clinical features of Granulomatous Chelitis

Answer 9

• Painless persistent swelling of one or both lips
• Small vesicles, erosions and scaling may occur

Thought that cheilitis granulomatosa is a monosymptomatic
form of Melkersson–Rosenthal syndrome or orofacial granulomatosis

Question 10

Laboratory tests of Granulomatous Chelitis

Answer 10

Histopathologic examination

Question 11

Granulomatous Chelitis Differential diagnosis

Answer 11

• Melkersson–Rosenthal syndrome
• Cheilitis glandularis
• Crohn’s disease
• Sarcoidosis
• Cystic fibrosis
• Lymphangioma,
• Angioedema

Question 12

Treatment of Granulomatous Chelitis

Answer 12

• Topical or systemic corticosteroids
• Tetracyclines
• Plastic surgery in severe cases

Question 13

Melkersson–Rosenthal Syndrome definition

Answer 13

• Rare disorder
• Characterised by Cheilitis
  granulomatosa, facial paralysis, fissured tongue,
• Less often intraoral and
  facial edema

Question 14

Melkersson–Rosenthal Syndrome Clinical diagnosis

Answer 14

Histologic examination

Question 15

Melkersson–Rosenthal Syndrome differential diagnosis

Answer 15

Identical to Granulomatous chelitis

Question 16

Treatment of Melkersson–Rosenthal Syndrome

Answer 16

Same as Granulomatous chelitis