5. Ephelides. Peutz-Jeghers syndrome.Fordyce syndrome. Flashcards
1
Q
Definition of Peutz–Jeghers Syndrome
A
- Rare genetic disorder
- Mucocutaneous pigmentation and hamartomatous polyps in GI tract
2
Q
Etiology of Peutz–Jeghers Syndrome
A
- Genetic
- Autosomal dominant trait in 70% cases
- 30% new mutations
3
Q
Clinical features of Peutz–Jeghers Syndrome
A
- Multiple, small round, ovoid or irregular shaped black/brown spots
- 1-10mm diameter
- Perioral skin, nose, eyes, lips, buccal mucosa and tongue
- Intestinal polyps- increased risk of malignant neoplasm
4
Q
Diagnosis of Peutz–Jeghers Syndrome
A
Laboratory tests
5
Q
Labooratory tests for Peutz–Jeghers Syndrome
A
- Histopathologic examination
- Intestinal endoscopy
- Radiographic examination of the gastrointestinal tract.
6
Q
Treatment of Peutz–Jeghers Syndrome
A
- Not required for mucocutaneous lesions
- Surgical excision of polyps if cause symptoms
- Regular checkups
7
Q
Fordyce Granules Definition
A
Ectopic sebaceous glands in oral mucosa
8
Q
Etiology of Fordyce’s Granules
A
Developmental-normal anatomical variation
9
Q
Clinical features of Fordyce’s Granules
A
- Multiple small, asymptomatic, slightly raised
- Whitish-yellow well circumscribed spots
- Rarely coalesce-form plaques
- Vermillion border of upper lip, commissures, buccal mucosa and retromolar region
10
Q
Diagnosis of fordyce granules
A
Based on clinical features
11
Q
Differential diagnosis of Fordyce’s Granules
A
- Candidiasis
- Lichen planus
- Leukoplakia
12
Q
Treatment of Fordyce’s Granules
A
No treatment required
