anti fungal drugs Flashcards
where do mycotic infections usually occur?
immunocromprimised hosts
what are the drug examples for anti fungal drugs
terbinafine and voriconazole
what is terbinafine used for
finger and toenail infections
what are the major groups of antifungal drugs
triazoles, echinocandins, imidazoles and polyenes
what drug group do fluconazole and voriconazole belong to
triazoles
what drug group does caspofungin belong to
enchinocandins
what drug group does ketoconazole belong to
imidazoles
what drug group does amphotericin B and nystatin belong to
polyenes
polyenes MOA
bind to cell membrane lining and results in fungal death
imidazoles and triazoles MOA
causes cell membrane to leak which results in altered cellular metabolism and fungal cell death
echinocandins MOA
prevent synthesis of fungal cell walls resulting in fungal cell death
what is the drug of choice for severe systemic fungal infections
amphotericin B
which drug passes into the cerebrospinal fluid
flucanzole
what are the premedications for fungal infections
antiemetics, antihistamines, antipyretics and corticosteroids
what do the premedications treat
prevent or minimize infusion related reactions due to amphotericin B
