antitubericular drugs Flashcards
what drugs are multi drug resistant tuberculosis resistant to?
isoniazid and rifampin
what is the primary drug in treating TB
isoniazid
which line drugs are isoniazid, ethambutol, pyrazinamide and rifampin
first line drugs (RIPE)
what line drugs are amikacin, levofloxacin and moxifloxacin
second line drugs
what are slow acetylators and what drug is it associated with
isoniazid and less is metabolized in the liver and it leads to toxicity
what are the adverse effects of isoniazid
peripheral neuritis, hepatotoxicity, hyperglycaemia and discolouration of body fluids
what is used to treat peripheral neuropathy associated with isoniazid use
vitamin B6
what age is ethambutol contradicted with
13 years and under
what are the adverse effects of ethambutol
visual changes (opitic neuritis, blindness, altered colour perception)
who is pyrazinamide contradicted in
patients with gout and severe liver disease
who is pyrazinamide not normally given to
pregnant people
what are the adverse effects of rifampin
red, brown and orange discolouration of tears, skin, sweat, urine, feces, septum, spinal fluid, and tongue
what is purified protein derivative
a diagnostic injection to diagnose TB and detect exposure
what is bacilli palmette-guerin
a vaccine injection that does not prevent TB but reduces active TB by 60-80%
