Abuse and Addiction Flashcards

1
Q

What are analgesics?

A

These are drugs that relieves pain.

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2
Q

What are examples of analgesics?

A

aspirin, ibuprofen, naproxen sodium, and morphine

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3
Q

What are aspirins?

A

Aspirin as well as similar drug are non-steroidal anti-inflammatory drugs (NSAIDs). These drugs relieve pain by reducing fever and inflammation.

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4
Q

Mechanism of action of aspirin

A

This is achieved by blocking the function of prostaglandins.

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5
Q

What is prostaglandins?

A

A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body.

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6
Q

What is meant by NSAID drugs?

A

A drug that works in a different way than a steroid to reduce pain, redness, swelling, and fever in the body. They do this by preventing the synthesis of prostaglandins thereby reducing inflammation + the pain associated with it.

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7
Q

What are pyrogens?

A

Pyrogens (“fire starters”) are released by the white blood cells
in response to an injury or infection.

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8
Q

How do pyrogens operate?

A

Pyrogens act on the hypothalamus and stimulate both the release of prostaglandins and heat – producing processes in the body.

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9
Q

How does morphine appear to reduce pain?

A

Attaching to sites called opiod receptors scattered throughout
the CNS and also in the GI tract.

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10
Q

What are the side effects of pain relief when morphine is used?

A

Sleepiness And a sense of wellbeing

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11
Q

Why does morphine give a pleasurable sensation?

A

Morphine also interacts with the sites of the brain that are activated by endorphins found in the brain.

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12
Q

What does endorphins mean?

A

“Endorphins” means “endogenous morphine”. As a result of its mimicry of endorphins, morphine can produce pleasurable sensations and euphoria.

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13
Q

What are depressants?

A

These are a class of drug that depresses the function of the CNS generally.

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14
Q

What are some effect of taking depressants?

A

Slowed heartbeat , reduction in anxiety, and in some cases the
promotion of sleep.

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15
Q

What are some examples of depressants?

A

Barbiturates, tranquilizers, sleep acids, and ethanol

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16
Q

How does the Benzodiazepine work?

A

Benzodiazepines are able to bind with GABA receptor sites and generate the inhibitory response resulting in CNS depression.

17
Q

What are hallucinogens?

A

These drugs alter the perception of time and reality and are often a difficult effect to quantify.

18
Q

Examples of hallucinogenic drugs?

A

LSD, mescaline, and marijuana and stimulants such as methamphetamines are hallucinogens.

19
Q

What are the two classes of hallucinogens?

A
  1. phenethylamine molecular skeleton
  2. tryptamines
20
Q

How does hallucinogens work?

A

Hallucinogens create their effect by interacting with receptors in the above neurotransmitter system.

21
Q

What is the difference between MDMA and psclobin?

A

Methamphetamine and ecstasy (MDMA, relates to amphetamines) are phenethylamines, while psiclobin, derived from psyclobin mushrooms, is a tryptamine.

22
Q

What is a narcotic?

A

Narcotic drugs have analgesic effects and tend to depress the CNS and promote sleep.

23
Q

What is the most popular narcotic?

A

Opiate alkaloids are the best known narcotics and include morphine, codeine, heroin, hydromorphone, oxycodone and hydrocodone.

24
Q

What is stimulants?

A

This group of drugs stimulates CNS function, induce alertness and interferes with sleep.

25
Q

What are common stimulants?

A

Cocaine, amphetamine and Methamphetamine

26
Q

How do stimulants act as hallucogenics?

A

At high doses many stimulants are hallucinogenic

27
Q

What is the mechanism of action of cocaine?

A

Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons.