Learning and memory II Flashcards

1
Q

Which of the following occurs from changes between one sensory system and the motor system

Relational learning
Motor learning
Perceptual learning
Stimulus response learning

A

Which of the following occurs from changes between one sensory system and the motor system

Relational learning
Motor learning
Perceptual learning
Stimulus response learning

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2
Q

Which of the following occurs from changes in one sensory system

Relational learning
Motor learning
Perceptual learning
Stimulus response learning

A

Which of the following occurs from changes in one sensory system

Relational learning
Motor learning
Perceptual learning
Stimulus response learning

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3
Q

Which of the following is learning about the relationship among individual stimuli

Relational learning
Motor learning
Perceptual learning
Stimulus response learning

A

Which of the following is learning about the relationship among individual stimuli

Relational learning
Motor learning
Perceptual learning
Stimulus response learning

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4
Q

How does learning alter brain structure? [1]

A

Experiences change the way we perceive, perform, think, and plan by physically altering neural circuits that participate in perceiving, performing, thinking, and planning

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5
Q

What are the three major stages that sustain learning and memory? [3]

A

Encoding
Storage
Retrieval

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6
Q

Explain the three major stages that sustain learning and memory:

Encoding [2]
Storage [1]
Retrieval [1]

A

Encoding:
* Acquisition: Sensory stimuli make the cut into-short-term memory
* Consolidation Changes in the brain stabilize memory over time, resulting in long-term memory
Creates a stronger representation over time

Storage:
* Represents the permanent record of the information

Retrieval
* accessing the stored information & using it to create a conscious representation or execute a learned behaviour

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7
Q

What are the different types of memories that we have? [3]

State the type of memory they

A

Very short lived: sensory memory

Short to medium lived: short-term memory; working memory

Long term

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8
Q

Very short term memory: sensory memory

Explain the two types of very short term sensory memory [2]

A

Echoic:
* short-lived persistence of the auditory sensory memory trace
* The auditory information just presented to you persists as a sort of echo in your head
* If you try to retrieve it quickly enough, it is still present and can be used

Iconic memory
* Short-lived persistence of the visual sensory memory trace

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9
Q

Very short term memory: sensory memory

How long do iconic and echoic memory last for? [2]

A

Echoic: The neural trace of an auditory stimulus is around 10 sec

Iconic memory: The neural trace of a visual stimulus is only 300 to 500 msec

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10
Q

Desribe The Atkinson and Shiffrin multi-store model of memory (1968)

A

Discrete stages of information processing occur during learning and memory:

Sensory memory –> Short term memory –> Long term memory

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11
Q

Describe the concept of working memory

A

A limited capacity store for retaining information over the short term (maintenance; sec to min), AND on focusing attention on AND performing mental operations on the contents of the maintained store (manipulation)

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12
Q

Where is the central executive processor in the brain? [1]

A

prefrontal cortex

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13
Q

Describe the pathway of long term memory potentiation in the hippocampus

A

Input to the hippocampus via the entorhinal cortex

To the granule cells of the dentate gryus

To the pyrimadal cells of CA3 hippocampal region via mossy fibres (neurones in the dentate gyrus)

From CA3 region either goes to:

  • via the fornix to the mamillary bodies. Which then connects to anterior nucleus of the thalamus. Projections go back to the cingulate gyrus and entorhinal cortex (AKA Papez’s circuit)

OR

  • CA3 axons project to CA1 via schaffer collaterals. The CA1 outputs convey the results of hippocampal processing, via the subiculum, back to the entorhinal cortex and sensory neocortex
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14
Q

Label C

Subiculum
Schaffer Collaterals
Mossy fibres
Pyramidal cells
Perforant pathway

A

Label C

Subiculum
Schaffer Collaterals
Mossy fibres
Pyramidal cells
Perforant pathway

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15
Q

Explain the difference in structure between AMPA and NMDA glutamate receptors [2]

A

NMDA:
* At normal resting membrane potentials are blocked by Mg2+
* Depolarisation of NMDA causes release of Mg2+ and unblocks the channel
* Glutamate can enter channel and Ca2+ influxes
* Ca2+ or Na+ can influx

AMPA:
* Opens in response to released glutamate and allow influx of Na+, which depolarises the neuron and produces an EPSP
* Can depolarise NMDA

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16
Q

LTP

Explain the synaptic changes that underlie simple forms of learning

A
  1. Activation of synapses
  2. Depolarization of the post-synaptic neuron
  3. NMDA receptors release Ca2+ (which can be triggered by activation via AMPA receptors on NDMA)
17
Q

LTP

Explain the difference between high frequency LTP occurs once versus iif high frequency input is repeated a few times

A

High frequency LTP repeated once:
* LTP lasts approx. 3 hours and decays.
* This transient, early LTP is not dependent on protein synthesis

High frequency LTP repeated many times:
* Form of late LTP occurs that lasts for approx. 24 hours
* Dependent on protein synthesis.
* Requires Ca2+ to activate a cascade of enzymes via cyclic AMP

18
Q

Long-term potentiation (LTP)

State the changes that occur pre-synaptically with LTP:

In early LTP [1]
In late LTP [1]

A

Early LTP: ncrease in the amount of glutamate released by the terminal buttons

In late LTP, an increased number of release sites increases the amount of glutamate released

19
Q

State the changes that occur post-synaptically with LTP [2]

A

Changes in the size and shape of dendritic spines

Growth of new dendritic spines

20
Q

State the changes that occur post-synaptically with LTP [2]

A

Changes in the size and shape of dendritic spines

Growth of new dendritic spines

21
Q

Why do we need long term depression of memories?

A

All active synapses would end up being strong.

As a necessary balance to learning-enhanced activity, there is also activity dependent long term depression

22
Q

Explain the mechanism of long term depression of memory [1]

(In hippocampus)

A

Hippocampus: where low-frequency long period stimulation depresses the EPSP for several hours.

  • Involves a decrease in the number of AMPA receptors
23
Q

Explain the difference in neural connections between early memory consolidation and late consolidation [3]

A

Connections between the hippocampus and various cortical modules are critical in early memory formation

Over time, the cortical modules form connections among themselves and the connections with the hippocampus become less important

When the memory is fully consolidated, only the cortical to cortical connections are important and the hippocampus becomes unnecessary

The retrieval cue accesses the memory directly from the cortical to cortical network of connections that form the unified representation of the memory

24
Q

Which area of the brain undergoes lesions to cause working memory loss?

Temporal
Frontal
Occipital
Parietal

A

Which area of the brain undergoes lesions to cause working memory loss?

Temporal
Frontal
Occipital
Parietal

25
Q

Which area of the brain undergoes lesions to cause long term memory loss?

Temporal
Frontal
Occipital
Parietal

A

Which area of the brain undergoes lesions to cause long term memory loss?

Temporal
Frontal
Occipital
Parietal

26
Q

Working memory (aka short term memory)

What is the name for the area that controls short term memory? [1]

A

Central executive [1]

27
Q

Working memory

Name and describe the inputs to the central execuative? [2]

A

Visuospatial sketchpad: a store for visual and spatial information.

Phonological loop: is a temporary store for verbal information and speech- holds thoughts in a speech-based form for 1-2 seconds.

28
Q

A patient presents with inability to recall lists told to him is likely caused by a lesion in which of the following?

Visuospatial sketchpad
Phonological loop

Where in the brain would this lesion be? [1]

A

Phonological loop: left posterior parietal lesion

29
Q

Lesions impacting the visuospatial working memory would occur from which regions of the brain? [2]

A

Left AND Right

Anterior occipital cortex: Broadmann area 19

Inferior posterior parietal lobe
Supramarginal gyrus
(Broadmann area 40)

30
Q

Working memory

Label A-E

A