susceptibility Flashcards
what is susceptibility
ability/affinity of acquiring a pathogenic microorganism and to allow/enable the pathogen to maintain itself within host
what is resistance
status of non-specific immunity (genetic and constitution) of host to specific infection
what is immunity
status of specific resistance to particular microorganism
based on existence of specific antibodies or sensitised T lymphocytes
mechanisms of resistance
general - mechanical, chemical, hormonal and microflora
cell factors
humoral factors
first line protection
mechanical, chemical and biological
second line of protection
phagocytosis, bactericidal and antitoxic strength of humoral and acquired/natural immunity
biological factors
skin and mucosa - pH 3-4, dryness, ciliary epithelium, lysosomes
fascia, blood, CSF, lymph
chemical factors
pH - fatty acid, gastric acid, bile acid
oxygen in tissue
hormonal factors
ACTH hormones
microflora
physiological ones = commensals
low pathogen
cellular factors
phagocytosis
macrophages
microphages
humoral factors
complement
properdin
opsons
lysosomes
factors that influence susceptibility
factors of general disposition - species, gender, breed, age
factors of individual disposition
factors of general disposition
species, breed, age, gender
factors of individual disposition
constitution, zoohygienic conditions, nutriton, exploitation, other comorbidities, tissue damages, transport, stress, immune status, environment, number os susceptible animals
