Bacterial pathogenesis - L5A Flashcards
what is an infection?
growth of micro-organisms within a host
what is a disease
damage that impairs host function
what is a pathogen
microorganism capable of causing disease
what is pathogenesis
process of disease
what is adhesion
ability of a microbe to attach to a surface
what is adhesins
bacterial factors mediating adherence
what’s colonisation
growth of microoganism in host
what does subclinical mean
asymptomatic infection
what is latent?
an infection with the potential to become active
what does opportunistic mean
infection caused by a microorganism that would not normally cause disease in a healthy host
what is pyogenic
pus forming microorganisms
what is fulminant
sudden and rapidly developing infections
infection process:
- exposure
- adherence
- invasion
- multiplication
what did Robert Koch work with?
bacillus anthracis (anthrax)
what did Robert koch show?
- Showed bacilli always present in those with infection
- merely correlative and wanted to prove causation
what was Koch’s four hypothesis?
- the pure culture grown must produce the same disease when inoculated into a healthy animal
- the same microbe must be re-isolated from the experimentally infected animal
- microbe must be present
- microbe should be isolated from host
why was koch’s hypothesis revolutionary
- mostly hold true
- opened door to new treatments
