(16) ALT - LIVER ENZYMES

Question 1

ALT aka

Answer 1

Serum Glutamic-Pyruvic Transaminase (SGPT)

Question 2

Action: transfer of an amino group between alanine & α-ketoglutarate

Answer 2

ALT (Alanine Aminotransferase)

Question 3

• ↑ in hepatocellular disorders

Answer 3

ALT

Question 4

NOTE:

o Fxn: Significant marker in hepatic disorders esp. in acute inflammatory conditions
▪ More liver-specific than AST
o More sensitive & specific screening test for post/transfusion hepatitis & occupational toxic exposure
o Used to screen blood donors

Answer 4

Diagnostic significance of ALT

Question 5

ALT is used to monitor:

Answer 5

o the course of hepatitis treatment
o effects of drug therapy esp. among pxs w/ chronic disorders

Question 6

o AST/ALT ratio
o Differentiates cause of hepatic disorder

▪ Ratio >1 → non-viral origin (AST is higher)
▪ Ratio <1 → viral origin (ALT is higher)

Answer 6

De Ritis Ratio

Question 7

ALT Coupling / 2ndary / indicator enzyme:

Answer 7

LDH

o Monitors ↓in absorbance @340nm → colorless product
▪ Product: Form of coenzyme is oxidized