(24) MISCELLANEOUS ENZYMES

Question 1

o A phosphoric monoester hydrolase
o Predominantly secreted in liver
o Marker for hepatobiliary dsz & infiltrative lesions of liver

Answer 1

5’N (nucleotidase)

Question 2

o Index of parenchymal fxn
o Secreted by liver
o Monitors effects of muscle relaxants (succinylcholine) after surgery
o Marker for insecticide / pesticide poisoning

Answer 2

Cholinesterase / Pseudocholinesterase

Question 3

Specific component of poison

Answer 3

organophosphate

Question 4

aka peptidylpeptidase or kinase II.

Answer 4

Angiotensin-Converting Enzyme (ACE)

Question 5

Converts angiotensin 1 to angiotensin 2 in lungs

Answer 5

Angiotensin-Converting Enzyme (ACE)

Question 6

inactive form of angiotensin

Answer 6

Angiotensin 1

Question 7

active form of angiotensin to regulate elecs, water retention, etc.

Answer 7

Angiotensin 2

Question 8

Main source of ACE:

Answer 8

▪ Macrophage
▪ Epitheloid cells of lungs

Question 9

↑ACE:

Answer 9

▪ Sarcoidosis
▪ Acute & Chronic bronchitis
▪ Leprosy

Question 10

Possible indicator of neuronal dysfxn

Answer 10

Which leads to dementia

Question 11

o Copper-carrying protein which acts as an enzyme
o Protein transporter for copper
o Marker for Wilson’s dsz (hepatolenticular dsz)

Answer 11

Ceruloplasmin

Question 12

For hepatobiliary dsz

Answer 12

Ornithine Carbamoyl Transferase (OCT)

Question 13

G6PD specimen

Answer 13

Red cell hemolysate, Serum

Question 14

o Maintains NADPH in the reduced form in the erythrocytes.
▪ Reduced NAD stabilizes the cell membrane to resist lysis / cell destruction caused by harmful agents.
o One of the newborn screening markers

Answer 14

G6PD

Question 15

G6PD is found in

Answer 15

adrenal cortex, spleen, RBC, & lymph nodes

Question 16

↓G6PD:

Answer 16

Drug dsz-associated HA (primaquine – prophylactic drug, antimalarial drug)

Question 17

↑G6PD:

Answer 17

MI, Megaloblastic anemia