Lecture4: Anterior Pituitary

Question 1

What is the mechanism of action of growth hormone?

Answer 1

Hormone action through a cytokine receptor

Question 2

How is Growth hormone secreted?

Answer 2

In a pulsatile manner

Question 3

What is the main source of IGF-1?

Answer 3

Liver

Question 4

How does IGF-1 increase bone growth?

Answer 4

Regulates chondrocytes

Question 5

Prolactin is mainly under inhibitory control by… released by…?

Answer 5

Dopamine released from the Hypothalamus

Question 6

Prolactin inhibits..?

Answer 6

Ovulation

Question 7

Prolactin is the major hormone of…?

Answer 7

Lactation

Question 8

Prolactin is responsible for…?

Answer 8

Breast development

Question 9

What is Prolactinoma?

Answer 9

A prolactin secreting tumour, the most commonly occurring pituitary tumour

Question 10

Explain Stalk Disconnection Syndrome

Answer 10

When a lesion compressed the pituitary stalk, dopamine can’t be delivered, which in itself is inhibitory, thus prolactin secretion increases

Question 11

How are Prolactinoma’s treated?

Answer 11

Via dopamine agonist Cabergoline

Question 12

What is Acromegaly?

Answer 12

GH excess in adults

Question 13

What is a characteristic sign of acromegaly?

Answer 13

Gaps between teeth often spotted by dentists

Question 14

Name a complication of acromegaly

Answer 14

Growth of the Viscera around the heart

Question 15

What is the somatostatin analogue of acromegaly called?

Answer 15

Octreotide