Lecture30: Insulin Synthesis And Regulation Flashcards
1
Q
Insulin is made from a single large precursor called?
A
Pre-proinsulin
2
Q
How is Proinsulin produced?
A
The pre peptide is removed, and the protein is folded with disulfide bridges
3
Q
The resulting pro insulin is transported to…?
A
Golgi complex
4
Q
in order for the insulin to be mature, the links between the A and B bridges are removed by enzyme…?
A
Protease
5
Q
What is secreted with insulin into the circulation?
A
C-peptide
6
Q
What is the most important stimulus of insulin secretion?
A
Glucose
7
Q
What allows entry of Glucose into the B cell?
A
GLUT2
8
Q
What does Glucokinase do?
A
Convert glucose to glucose 6-phosphate, the starting point of glucose metabolism
9
Q
Insulin in blood has a short half-life of?
A
3-5 minutes
10
Q
What does insulin do in the liver?
A
Increases glucokinase expression
