Lecture42: Factors Affecting GFR

Question 1

Glomerulonephritis and DM affect what of the glomerulus?

Answer 1

The permeability, they decrease it

Question 2

Contraction of mesangial cells by angiotensin 2 lead to…?

Answer 2

Decreased surface area

Question 3

When renal blood flow increases, what happens to the GFR?

Answer 3

It increases

Question 4

What is the ABP safe range that leads to no change of the GFR?

Answer 4

80-160mmHG

Question 5

When the Intracapsular pressure increases, what happens to the GFR?

Answer 5

It decreases

Question 6

What might cause an increase in the intracapsular pressure?

Answer 6

Renal pelvic stones or tumours

Question 7

A decrease in colloid osmotic pressure leads to?

Answer 7

Increased GFR

Question 8

does Hypoproteinemia lead to decreased colloid osmotic pressure?

Answer 8

Yes

Question 9

The myogenic mechanism regulates the GFR, what does it respond to?

Answer 9

ABP changes

Question 10

What does the Tuberoglomerular feedback respond to?

Answer 10

Changed in NaCL in tubular fluid

Question 11

Explain the myogenic mechanism?

Answer 11

The afferent arteriolar smooth muscles change their contraction in response to the renal perfusion pressure

Question 12

Example of myogenic mechanism?

Answer 12

When ABP increases and stretches the wall, the wall then contracts in response and the opposite is true

Question 13

Explain the Tubero-glomerular feedback mechanism?

Answer 13

It’s where the GFR in each nephron is regulated according to the solute flow through that nephron

Question 14

Is the TGF a feedback loop?

Answer 14

Yes

Question 15

How does Hypertension affect the GFR

Answer 15

Increases it

Question 16

How does Hypotension affect the GFR?

Answer 16

Decreases it