Lecture31: Insulin Receptors Flashcards
What are the cellular insulin receptors?
TK receptors
What is Receptor Dimerization?
When the ligand binding causes a conformational change that causes two receptors to associate together
Dimerization results in?
Activation of the intrinsic TK activity and phosphorylation
The insulin receptor gene is coded by?
Chromosome 19
Chromosome 19 is expressed everywhere bar…?
Brain
Which enzyme mediates the anabolic actions of insulin?
PI3K
How does PI3K mediate anabolic actions?
Via GLUT4 receptor transduction from the cell to the cell membrane
The mitogenic actions of insulin are…?
Promotion of cell growth, division and what not
The mitogenic actions are activated via?
The MAP Kinase pathway
After receptor use, what happens to them?
They are processed by lysosomes to be recycled
What is the insulin receptor half life?
7 hours
In Type 2 DM, what is the cause of insulin resistance?
Impaired signaling from the receptor
Why do diabetic mothers have big babies?
The baby produces it’s insulin, couple that with
The mother’s high level,
This results in large deposits of fat
What is GLUT4 found?
Skeletal muscle
