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NAPLEx > oncology II > Flashcards

oncology II Flashcards

1
Q

selective estrogen receptor modulatorsm

A
  • SERMs
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2
Q

tamoxifen

A

soltamox
- SERMs

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3
Q

tamoxifen info:

A
  • increase risk of uterine or endometrial cancer
  • QT prolongations
  • increase risk of thromboembolic event
  • hypo K and Mg
  • hot flashes/ night sweats etc.
  • decreases bone density… supplement w/ Ca and vitamin D
  • teratogenic
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4
Q

fulvestrant

A

Faslodex
IM only
- selective estrogen receptor degrader (SERD)

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5
Q

anastrozole

A

Arimidex
- aromatase inhibitor

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6
Q

letrozole

A

Femara
- aromatase inhibitor

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7
Q

exemestane

A

Aromasin
- aromatase inhibitor

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8
Q

trastuzumab

A

Herceptin
need HER2 positive
- mab

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9
Q

gonadotropin-releasing hormone agonist

A

GnRH agonists
also known as luteinizing hormone-releasing hormone (LHRH) agonists, they reduce testosterone through a negative feedback mechanism, causing an initial surge in test followed by gradual reduction

  • will cause decrease in bone density, sue w/ Ca and vitamin D
  • tumor flare: prevent w/ concurrent sue of antiandrogent
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10
Q

leuprolide

A

Lupron Depot
- GnRH agonists

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11
Q

Goserelin

A

Zoladex
- GnRH agonists

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12
Q

GnRH antagonists

A

block GnRH directly causing a rapid decrease in testosterone productions

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13
Q

degarelix

A

firmagon
- GnRH antagonists

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14
Q

Relugolix

A

Orgovyx
- GnRH antagonists

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15
Q

bicalutamide

A

Casodex
- first gen, antiandrogens

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16
Q

Nilutamide

A

Niladron
- night blindness, DISULFIRAM reactions (avoid OH)
- first gen, antiandrogens

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17
Q

apalutamide

A

erleada
- seizures risk and QT prolongation
- second gen, antiandrogens

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18
Q

darolutamide

A

Nabeqa
- neutropenia
- second gen, antiandrogens

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19
Q

enzalutamide

A

Xtandi
- seizures risk
- second gen, antiandrogens

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20
Q

Abiraterone

A

Zytiga
- androgen biosynthesis inhibitors

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21
Q

BSA (m^2)

A

= sq root of ((Ht(cm) x Wt(kg))/ 3600)

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22
Q

Cyclophosphamide
Ifosfamide

A

Ifex
- dispensed w/ Mesna
- alkylating agents

23
Q

carmustine

A

BiCNU, Gliadel Wafer)
- alkylating agents

24
Q

Lomustine

A

Gleostine
- alkylating agents

25
Q

Busulfan

A

Myleran
- alkylating agents

26
Q

Cisplatin

A
  • platinum-based compounds
27
Q

Carboplatin

A
  • platinum-based compounds
28
Q

oxaliplatin

A
  • platinum-based compounds
29
Q

Doxorubicin

A

adriamycin
keep track of lifetime accumulation of dose
450-550 max, totect when >300 cumulative dose
- anthracyclines

30
Q

Mitoxantrone

A
  • anthracyclines
31
Q

Irinotecan

A

Camptosar
- topoisomerase I inhibitors

32
Q

Bleomycin

A
  • topoisomerase II inhibitors
33
Q

etoposide

A
  • topoisomerase II inhibitors
34
Q

vincristine

A
  • vinca alkaloids
35
Q

vinblastine

A
  • vinca alkaloids
36
Q

paclitaxel

A
  • taxanes
37
Q

docetaxel

A
  • taxanes
38
Q

fluorouracil

A

“5-FU”
- pyrimidine analog antimetabolites

39
Q

capecitabine

A

Xeloda
- pyrimidine analog antimetabolites

40
Q

methotrexate

A

trexall, otrexup, rasuva
- folate antimetabolites

41
Q

pemetrexed

A

alimta
- folate antimetabolites

42
Q

pralatrexate

A

folotyn
- folate antimetabolites

43
Q

in autoimmune disease
folate

A
  • dose of methotrexate is much lower
  • folic acid is recommend prophylactically to reduce SE
  • leucovorin is NOT used unless the pt does not respond to folic acid
44
Q

in oncological disease
folate

A
  • dose of methotrexate is much higher
  • rescue the pt from high- dose tox, a reduced form of folate must be started after methotrexate has a chance to kill the chance cancer cells. Leucovorin or levoleucovorin is given
  • regular folate is not effective in rescue
  • folate is sued w/ pemetrexed and pralatrexate to reduce SE
45
Q

ci

A

circulatory system
- moncolonal antiboides

46
Q

tu

A

tumor
- moncolonal antiboides

47
Q

li

A

immune system
- moncolonal antiboides

48
Q

bevacizumab

A

Avastin
impairs wound healing: do not administer 28 days before or after surgery
- vascular endothelial growth (VEGF) inhibitors

49
Q

trastuzumab

A

Herceptin
need HER2 positive before start
monitor LVEF
- human epidermal growth factor 2 (HER2) inhibitor

50
Q

cetuximab

A

Erbitux
- epidermal growth factor preceptor (EGFR) inhibitors

51
Q

rituximab

A

Rituxan
- leukocyte cluster of differentiation (CD) antigens inhibitors

52
Q

pembrolizumab

A

keytruda
- programmed death receiptor-1 (PD-1) inhibitor

53
Q

ipilimumab

A

yervoy
- CTLA-4 inhibitor
cytotoxic T-lymphocyte antigen-4

54
Q

imatinib

A

gleevec
- tyrosin kinase inhibitors

NAPLEx (75 decks)

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