28 - ECM

Question 1

What is the ECM broadly? What important macromolecules does it contain? What does it do?

Answer 1

Question 2

Do you know these?

Answer 2

review

Question 3

What is the structure and function of collagen? Where is it found?

Answer 3

Question 4

How is collagen synthesized?

Answer 4

Question 5

What residues make up collagen? Why is this important?

Answer 5

Question 6

How is the triple helix stabilized and strengthened (overview)?

Answer 6

Question 7

What is fibrillar collagen?

Answer 7

Question 8

What are the types of collagen?

Answer 8

Question 9

What are some structural variations in collagen?

Answer 9

Question 10

What are elastic fibers (overview)? Where are they found? What are their general structure, composition, and function?

Answer 10

Question 11

What is a disease associated with improper elastic fiber production?

Answer 11

Question 12

What is fibronectin? What is it used for? What is its general structure and function?

Answer 12

Question 13

What are fibronection isoforms? How are they made? What are the consequences of this?

Answer 13

Question 14

What does mutations in fibronection formation cause?

Answer 14

Question 15

What are proteoglycans? General structure and function?

Answer 15

Question 16

What are glycosaminoglycans (GAGs)? General structure and function? Common ones?

Answer 16

Question 17

What is the basement membrane generally? What is it composed of/contain? General structure and function?

Answer 17

Laminins, type 4 collagen, perlecan, nidogen (entactin)

Question 18

What are laminins?

Answer 18

Question 19

What is type 4 collagen?

Answer 19

Question 20

What is perlecan? What do mutations in perlecan result in?

Answer 20

Question 21

What is nideogen (entactin)? General structure and function?

Answer 21

Question 22

What is the function role of the basal lamina (which contains the basement membrane)?

Answer 22

Question 23

What is Alport’s syndrome? What does it affect? Common symptoms?

Answer 23

Question 24

Why is ECM remodeling necessary? How is it performed? What molecules are most relevant?

Answer 24

Question 25

What are matrix metalloproteinases (MMPs)? What do they do? How are they classified?

Answer 25

Question 26

What is the structure of MMPs? How does that relate to their function?

Answer 26

Question 27

What are some relatives of MMPs (molecules with similar function of MMPs)? What are the structural similarities?

Answer 27

Question 28

What are TIMPs (tissue INHIBITORS of metalloproteinases)?

Answer 28

Question 29

How do MMPs and TIMPs function in development and disease?

Answer 29

Question 30

What are the modes of action of MMPs?

Answer 30

Question 31

How does epithelial branching morphogenesis depend on the balance of MMPS and TIMPs?

Answer 31

Question 32

What is the role of MMPs in dermal wound healing?

Answer 32

Question 33

What is the role of MMPs in the replacement of normal tissue with fibrotic tissue?

Answer 33