35 - Pharmacodynamics I

Question 1

do u know

Answer 1

review

Question 2

What are drug receptors (broadly)?

Answer 2

Question 3

How do drugs interact with their receptors?

Answer 3

Question 4

What are the basics of receptor agonist and antagonist interaction?

Answer 4

Question 5

Describe the concept of signal transduction generally

Answer 5

Question 6

Describe the basics of signal transduction pathways and how pharmacodynamics plays a role in the interaction of multiple pathways.

Answer 6

Question 7

What is biased agonism?

Answer 7

Question 8

What is the concept of signal amplification generally? Why is that important in pharmacodynamics?

Answer 8

best to implement drugs upstream before signal amplification

Question 9

What are common sites of cellular drug receptors? How does this affect drug design?

Answer 9

Question 10

What cellular molecules or features are usually major cellular drug targets?

Answer 10

Question 11

What are some extracellular drug targets?

Answer 11

Question 12

What are therapeutic monoclonal antibodies?

Answer 12

Question 13

What is the concept of “spare” receptors in agonist antagonist interaction?

Answer 13

essentially like competitive inhibition

Question 14

How do cellular receptors respond to drugs over time? Do they stay constant?

Answer 14

downregulation and upregulation of receptors can occur in the short or long term

Question 15

describe the process of receptor down-regulation

Answer 15

Question 16

Describe the process of receptor upregulation

Answer 16