[14] UCP1 Flashcards
What is UCP1?
A protein located in the inner mitochondrial membrane that is involved in thermogenesis.
Where is UCP1 located?
In the inner mitochondrial membrane.
What is the full form of UCP1?
Uncoupling Protein 1.
What is the main function of UCP1?
To generate heat by dissipating the proton gradient generated by the electron transport chain.
How does UCP1 work?
It allows protons to re-enter the mitochondrial matrix without going through ATP synthase, dissipating the proton gradient and releasing energy as heat.
In which cells is UCP1 primarily found?
In brown adipose tissue (brown fat).
What is the role of UCP1 in brown adipose tissue?
It contributes to non-shivering thermogenesis, a process that generates heat without muscle contractions.
What is the relevance of UCP1 in newborns and hibernating mammals?
It helps them to maintain body temperature in cold environments.
What does BAT stand for?
Brown Adipose Tissue.
What is thermogenesis?
The process of heat production in organisms.
What is the difference between shivering and non-shivering thermogenesis?
Shivering thermogenesis involves muscle contractions to generate heat, while non-shivering thermogenesis generates heat without muscle contractions, primarily through the action of UCP1 in brown fat.
How does UCP1 affect ATP production?
By dissipating the proton gradient, it decreases the efficiency of ATP production.
Why is UCP1 called an “uncoupling” protein?
Because it uncouples the electron transport chain from ATP production, allowing energy to be released as heat instead.
What is the role of UCP1 in obesity?
Research suggests that UCP1 activity could influence body weight by affecting energy expenditure; however, the relationship is complex and not fully understood.
How does UCP1 impact energy expenditure?
By dissipating energy as heat rather than storing it or using it for ATP production.
