prelim !

Question 1

byproduct of the reformation of an endoplasmic reticulum when the eukaryotic cells break
up – absent in healthy living cells

Answer 1

microsomes

Question 2

produces microsomes

Answer 2

smooth ER

Question 3

other name for mixed function oxidases

Answer 3

monooxygenases

Question 4

the one who will donate ectrons to yield a molecular oxygen that will appear in the metabolite of a drug

Answer 4

hydride ions

Question 5

the one responsible for allowing the mixed function oxidases to donate oxygen

Answer 5

NADPH

Question 6

two enzymes of mixed function oxidase

Answer 6

• flavoprotein, NADPH-cytochrome reductase
• cytochrome P450

Question 7

is a hemoprotein containing an iron atom that can alternate between the ferrous (Fe++) and
ferric (Fe+++) states

Answer 7

cytochrome P450

Question 8

refers to the mixed-function oxidation of aromatic compounds (arenes) to their corresponding phenolic metabolites (arenols)

Answer 8

oxidation aromatic moieties

Question 9

the most important pathway by which arene oxide is converted to arenol – a spontaneous rearrangement of the structure of arene oxide to become arenol

Answer 9

NIH shift

Question 10

just with the addition of water with the aid of enzymes – it will yield trans-dihydrodiols

Answer 10

enzymatic hydration (epoxide hydrase)

Question 11

a major detoxification pathway – yields glutathione metabolite

Answer 11

glutathione conjugation

Question 12

more stable than the arene oxides formed from aromatic compounds

Answer 12

epoxides