Drugs: (DNA synthesis Inhibitors) S phase

Question 1

methotrexate
pemetrexed

Answer 1

inhibit DHFR and inhibit DNA synthesis

Question 2

rescue drug for methotrexate and pemetrexed that is the treatment for their side effects

Answer 2

Leucovorin

Question 3

Azathioprine
6-mercaptopurine

Answer 3

block purine synthesis

side effects: EB virus

Question 4

rescue drug for azathioprine and 6-mercaptopurine

Answer 4

Allopurinol

Question 5

drugs ending in (-bine) inhibit

Answer 5

DNA polymerase

Question 6

Cytarabine
Gemcitabine
Fludarabine
Clofarabine
Nelarabine

Answer 6

inhibits DNA Polymerase (no DNA replication)

Question 7

5-Fluorouracil (5-FU)

Answer 7

inhibits thymidylate synthetase (limits thymidine availability for DNA synthesis)