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PFM: Biweekly Exam 2 > Drugs: Topoisomerase I Inhibitors > Flashcards

Drugs: Topoisomerase I Inhibitors Flashcards

1
Q

drugs that end in -tecan inhibits what

A

topoisomerase I

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2
Q

Irinotecan
Topotecan

A

inhibit topoisomerase I

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3
Q

side effects of Irinotecan and Topotecan

A

diarrhea

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4
Q

Deruxtecan

A

inhibits topoisomerase I

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5
Q

Deruxtecan combined with what drug allows HER2 neighbor cells to be killed (bystander effect)

A

Trastuzumab

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6
Q

hydroxyurea

A

inhibits ribonucleotide reductase
(blocks transformation of UDP to dUDP (pyrimidine synthesis)

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PFM: Biweekly Exam 2 (20 decks)

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