Drugs: DNA-Alkylating and Intercalating/Topoisomerase II

Question 1

cyclophosphamide

Answer 1

cross links DNA (prevents cancer cells from growing)

Question 2

side effects of cyclophosphamide

Answer 2

hemorrhagic cystitis (inflammation of bladder)

Question 3

rescue drugs (2) for side effects of cyclophosphamide

Answer 3

N-acetylcysteine and MESNA

Question 4

Cisplatin

Answer 4

cross links DNA (prevents cancer cells from growing)

Question 5

side effects of cisplatin

Answer 5

nephrotoxicity (damages kidneys)

Question 6

drugs that end in (-cin) inhibit what

Answer 6

topoisomerase II

Question 7

daunorubicin
doxorubicin

Answer 7

inhibits topoisomerase II (distorts double helix)

Question 8

side effects of daunorubicin and doxorubicin

Answer 8

cardiac damage

Question 9

rescue drug for daunorubicin and doxorubicin that is used to treat the side effects

Answer 9

Dexrazoxane

Question 10

Bleomycin

Answer 10

inhibits topoisomerase II (distorts double helix)

Question 11

side effects of bleomycin

Answer 11

pulmonary fibrosis

Question 12

Etoposide
Teniposide

Answer 12

inhibits Topoisomerase II