Anti-Fungal Part 3 Flashcards
5-Fluorocytosine + Amphotericin =
Cryptococcal meningitis
5-Fluorocytosine + Itraconazole
Chromoblastomycosis
Orally active antifungal
Very narrow spectrum of activity, prone to resistance
Orally active antifungal
For serious systemic infections caused by Candida and Cryptococcus sp.
5-Fluorocytosine
agents that contain, in their structure, at least two double bonds, and a lactone ring.
Antifungal antibiotics (Polyenes)
broad spectrum antifungal agents with potent activity against yeasts, molds, and dermatophytes
Antifungal antibiotics (Polyenes)
The most effective agent in the treatment of systemic fungal infection (IV- severe form) especially the immunocompromised patient
Amphotericin B (Fungizone)
Amphotericin B has Fungistatic at low concentration; fungicidal at high concentration T/F
True
Side effects of Amphotericin B
Phlebitis
Chills
Nephrotoxicity
Hemolytic activity
Amphotericin B Binds to ergosterol and alters the permeability of the cell by forming amphotericin 𝛽-associated pores in the cell membrane. T/F
True
The smallest type of macrocycle; a pentaene
Obtained from cultures of S. natalensis
Used topically to treat superficial mycotic infections of the eye
Natamycin (Also known as Pimaricin)
Natamycin (Pimaricin) Causes both potassium ion leakage and cell lysis at the same concentration. T/F
True
Penicillium griseofulvum
Used for Systemic treatment of tinea infections/dermatophytosis
Refractory ringworm infections of body, nails, hair, and feet
Griseofulvin
Griseofulvin Oral absorption provides a systemic effect; should be given with a fatty meal
T/F
True
Griseofulvin Inhibits fungal cell activity by interfering with mitotic spindle structure T/F
True
