Anti-Fungal Part 5

Question 1

Orally used for systemic mycoses

Available as 2% cream

Known to inhibit cholesterol biosynthesis

The only water soluble

Adverse effect: Hepatotoxic

Answer 1

Ketoconazole Nizoral ®

Question 2

Supplied as 1% cream used for candidiasis

Answer 2

Econazole nitrate (Spectrazole)

Question 3

As1%creamforlocaltinea infections

Answer 3

Sulconazole nitrate (Exelderm)

Question 4

More effective against Torulopsis glabarata, supplied as 6.5% ointment

Answer 4

Tioconazole

Question 5

Local and systemic infections in injectable form

Answer 5

Miconazole

Question 6

Acidic environment is required, reduce acidity reduces the GI absorption of the drug.

Effective and better tolerated than Ketoconazole

Answer 6

Itraconazole (Sporanox)

Question 7

Treatment of choice for Cryptococcal meningitides, plasma binding is less than 10%

Answer 7

Fluconazole Diflucan ©

Question 8

Acts as a tight-binding noncompetitive inhibitor of the enzyme inositol phosphoryl ceramide synthase

Produced by fermentation in cultures of Aureobasidin
pullulan

Answer 8

Aureobasidin A

Question 9

Napthacenequinones that bind mannan in the presence of Ca2+ to disrupt the cell membrane in pathogenic fungi

Against Candida spp. And Cryptococcus neoforman

Answer 9

Pradimycins and Benanomycin