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BIOQUÍMICA > Síntesis de Purinas y pirimidinas > Flashcards

SĂ­ntesis de Purinas y pirimidinas Flashcards

1
Q

Contienen 2 anillos en su estructura

A

Purinas

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2
Q

Contiene 1 anillo en su estructura

A

Pirimidinas

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3
Q

Menciona a las Purinas

A
  • Adenina
  • Guanina
    Pure As Gold
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4
Q

Menciona a las Pirimidinas

A
  • Citosina
  • Uracilo
  • Timina
    CUT Pie
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5
Q

Diferencia entre adenina y adenosina

A

Adenina es una base nitrogenada y la adenosina un nucleĂłsido

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6
Q

Estructura de un nucleĂłtido

A
  • Base nitrogenada
  • Fosfato
  • AzĂșcar
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7
Q

Estructura de un nucleĂłsido

A
  • Base nitrogenada
  • AzĂșcar
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8
Q

Principal precursor de la sĂ­ntesis de purinas y pirimidinas

A

Ribosa

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9
Q

Enzima que cataliza la reacción de Ribosa-5-P –> PRPP

A

PRPP sintetasa (fosforibosil pirofosfato)
*utiliza ATP

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10
Q

Intermediario principal para la sĂ­ntesis de purinas y pirimidinas

A

IMP = inosina monofosfato

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11
Q

Cofactores para la formaciĂłn de IMP

A
  • Guanina
  • Aspartato
  • Glicina
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12
Q

¿Con qué se relacionan las deficiencias de purinas?

A

A la falta de ĂĄcido fĂłlico durante el embarazo (porque el tetrahidrofolato (THF) es un cofactor para formar IMP)

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13
Q

IMP + Aspartato –> Adenosilsuccinato

A

Enzima: Adenosuccinato sintetasa
Utiliza GTP

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14
Q

Adenosuccinato –> AMP

A

Enzima: Adenosuccinato liasa
Sale fumarato –> KREBS

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15
Q

IMP –>XMP (xantosina monofosfato)

A

Enzima: IMP DH
Utiliza NAD+ sale NADH

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16
Q

XMP + Glutamina –> GMP + Glutamato

A

Enzima: GMP sintetasa
Utiliza ATP

17
Q

Principal sustrato para la sĂ­ntesis de pirimidinas

A

Carbamoil fosfato

18
Q

Glutamina –> Carbamoil fosfato + Glutamato

A

Enzima: Carbamoil fosfato sintetasa - II
Utiliza CO2 y 2ATP

19
Q

Ácido orótico + PRPP –> UMP

A

Enzima: UMP sintasa

20
Q

UMP –> UDP –> ???

A

GTP

21
Q

UDP –> dUDP

A

Enzima: RibonucleĂłtido reductasa

22
Q

dUDP –> dTMP

A

Enzima: Timidilato sintasa

23
Q
A
24
Q
A

BIOQUÍMICA (16 decks)

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