Test #4 Anti-Inflammatory Flashcards
What is the rhythm called when you body produces a neg feedback. Once your body produces enough cortisol for the day it starts to decrease until midnight
Diurnal rhythm
What are the main MOA of glucocorticoids? (steroids)
Increase adrenergic drug activity
Vascular effects
limits damage to spinal cord in trauma
In the Arachidonic acid cascade; glucocorticoids can block _____ this is at the very beginning of the cascade which produces an anti-inflammatory effect.
Phospholipase A2 (PLA2)
by blocking this you block the sensitization
What do all Prostaglandins do
cause sensitization of the neurons
You can not give glucocorticoids to what type of patients
Diabetic patients
What are 3 biological effects of glucocorticoids?
- increase energy by increaseing production of glucose and glycogen
- bone catabolism - osteoporosis
- fetal growth - surfactant
What are two SE of the eyes of long term use of steroids?
Eyes bulging and cataracts
What disease is caused by an overproduction of glucocorticoids? you have a moon face, buffalo hump and purple striae
Cushings
What disease is caused by a deficiency of of glucocorticoids
Primary - adrenal cortex not producing cortisol (surgical removal or pituitary
Secondary - ACTH deficiency
Addison’s disease
How do you treat Addison’s disease?
Replacement therapy - alternate day therapy - use an intermediate acting (24-36hr) every other day
Prednisone, Triamcinilone, or Methylprednisone
What are two SE of long term use of steroids?
infection (d/t immunosuppression) and osteoporosis
Where are glucocorticoids synthesized?
In the zona fasciculata of the adrenal cortex
What receptors do steroids exert their effects through to translocate on the nucleus to get to the DNA
Cytosolic receptors
What are three effects of Glucocorticoids?
Anti-insulin, anti-immune, and anti-inflammatory
Name 2 glucocorticoids that have a plasma t1/2 life of 30mins and a bio t1/2 of 8-12 hrs
Best for mineralocorticoids effects
Cortisone and hydrocortisone
