pharmacology summary Flashcards
1
Q
Affinity –
A
strength of association between ligand and receptor
2
Q
Efficacy –
A
ability of an agonist to evoke a cellular response
3
Q
agonist
A
possess affinity + efficacy
4
Q
antagonist
A
possess only affinity not efficacy
5
Q
what is pKa
A
pH at which 50% of drug is ionised
6
Q
Henderson-Hasselbalch equation:
A
pH – pKa = log(A-/AH) = acid
7
Q
enteral administration route
A
Oral, sublingual, Rectal
8
Q
parenteral administration route :
A
IV, IVM, subcutaneous, inhalational
9
Q
Vd < 10L =
A
vascular compartment
10
Q
Vd 10-30L =
A
Extracellular water
11
Q
Vd > 30L =
A
Total body water
12
Q
Vd –
A
volume in which drug is dissolved
13
Q
higher TR
A
safer the drug
14
Q
kinetics
A
elimination at a constant rate
15
Q
Clearance =
A
volume of plasma cleared of drug in unit time