Citric Acid Cycle Flashcards

1
Q

Describe the Function of the cycle

A

To generate energy (ATP) from acetyl CoA & OAA (oxaloacetate) to form citrate

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2
Q

What is generated from the cycle

A

By product- CO2
6 NADH
2 FADH2
2 ATP

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3
Q

Describe the process of the cycle

A

Citrate- Citrate ( acetyl CoA + OAA by citrate synthase)
Is- Isocitrate ( isomer of citrate by acconitase)
Kerbs- a- ketogluterate ( by isocitrate D.H.)
Starting- succinyl CoA (by a-KG D.H.)
Substrate- succinate (by succinyl CoA synthetase)
For- fumerate (by succinate D.H.)
Making- malate (by fumerase)
OAA- oxaloacetate ( by malate D.H.)

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4
Q

Which reactions involve electron carriers

A

Isocitrate -> a- KG
A-KG -> succinyl CoA
Succinate -> fumerate
Malate -> OAA

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5
Q

Which reactions release CO2

A

Isocitrate -> a- KG
A-KG -> succinyl CoA

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6
Q

Describe links to other pathways

A

Pyruvate comes from glycolysis
Links to the electron transport chain
Links to terminal respiration

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7
Q

Which reactions are reversible

A

Citrate to isocitrate
Succinate to fumerate
Fumerate to malate
Malate to OAA

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8
Q

Where does the cycle take place and in what conditions

A

Mitochondria, aerobic

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9
Q

What are the main inhibitors and catalysts

A
  • = ATP, NADH, citrate
    += Ca2+, ADP
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