Citric Acid Cycle Flashcards
Describe the Function of the cycle
To generate energy (ATP) from acetyl CoA & OAA (oxaloacetate) to form citrate
What is generated from the cycle
By product- CO2
6 NADH
2 FADH2
2 ATP
Describe the process of the cycle
Citrate- Citrate ( acetyl CoA + OAA by citrate synthase)
Is- Isocitrate ( isomer of citrate by acconitase)
Kerbs- a- ketogluterate ( by isocitrate D.H.)
Starting- succinyl CoA (by a-KG D.H.)
Substrate- succinate (by succinyl CoA synthetase)
For- fumerate (by succinate D.H.)
Making- malate (by fumerase)
OAA- oxaloacetate ( by malate D.H.)
Which reactions involve electron carriers
Isocitrate -> a- KG
A-KG -> succinyl CoA
Succinate -> fumerate
Malate -> OAA
Which reactions release CO2
Isocitrate -> a- KG
A-KG -> succinyl CoA
Describe links to other pathways
Pyruvate comes from glycolysis
Links to the electron transport chain
Links to terminal respiration
Which reactions are reversible
Citrate to isocitrate
Succinate to fumerate
Fumerate to malate
Malate to OAA
Where does the cycle take place and in what conditions
Mitochondria, aerobic
What are the main inhibitors and catalysts
- = ATP, NADH, citrate
+= Ca2+, ADP