Citric Acid Cycle

Question 1

Describe the Function of the cycle

Answer 1

To generate energy (ATP) from acetyl CoA & OAA (oxaloacetate) to form citrate

Question 2

What is generated from the cycle

Answer 2

By product- CO2
6 NADH
2 FADH2
2 ATP

Question 3

Describe the process of the cycle

Answer 3

Citrate- Citrate ( acetyl CoA + OAA by citrate synthase)
Is- Isocitrate ( isomer of citrate by acconitase)
Kerbs- a- ketogluterate ( by isocitrate D.H.)
Starting- succinyl CoA (by a-KG D.H.)
Substrate- succinate (by succinyl CoA synthetase)
For- fumerate (by succinate D.H.)
Making- malate (by fumerase)
OAA- oxaloacetate ( by malate D.H.)

Question 4

Which reactions involve electron carriers

Answer 4

Isocitrate -> a- KG
A-KG -> succinyl CoA
Succinate -> fumerate
Malate -> OAA

Question 5

Which reactions release CO2

Answer 5

Isocitrate -> a- KG
A-KG -> succinyl CoA

Question 6

Describe links to other pathways

Answer 6

Pyruvate comes from glycolysis
Links to the electron transport chain
Links to terminal respiration

Question 7

Which reactions are reversible

Answer 7

Citrate to isocitrate
Succinate to fumerate
Fumerate to malate
Malate to OAA

Question 8

Where does the cycle take place and in what conditions

Answer 8

Mitochondria, aerobic

Question 9

What are the main inhibitors and catalysts

Answer 9

• = ATP, NADH, citrate
  += Ca2+, ADP