prolactin FA 01-16

Question 1

Prolactin 2 functions?

Answer 1

lactogenesis and breast growth (with estrogen)

Question 2

prolactin is structural homolog to what?

Answer 2

growth hormon

Question 3

What inhibits prolactin synthesis?

Answer 3

dopamine

Question 4

What activates prolactin synthesis?

Answer 4

TRH

Question 5

How prolactine inhibits its release?

Answer 5

Promotes dopamine release from hypothalamus –> release of dopamine –> inhibits prolactin

Question 6

Pregnancy (estrogen) on prolactin?

Answer 6

stimulates

Question 7

breastfeeding on prolactin?

Answer 7

stimulates

Question 8

Sleep on prolactin?

Answer 8

stimulates

Question 9

stress on prolactin?

Answer 9

stimulates

Question 10

TRH on prolactin?

Answer 10

stimulates

Question 11

dopamine antagonists on prolactin?

Answer 11

stimulates

Question 12

dopamine on prolactin?

Answer 12

inhibits

Question 13

somatostatin on prolactin?

Answer 13

inhibits

Question 14

dopamine agonists (bromocriptine) on prolactin?

Answer 14

inhibits

Question 15

prolactin on prolactin?

Answer 15

inhibits (negative inhibition vie dopamine release)

Question 16

what milk components are synthesized due to prolactin?

Answer 16

casein and lactose

Question 17

prolactin effect on GnRH?

Answer 17

inhibits

Question 18

what happens when prolactin inhibits GnRH?

Answer 18

decr FSH and LH –> decr. ovulation and spermatogenesis

Question 19

insult to anterior pituitary –> what happens to prolactin?

Answer 19

decr. prolactin -> no lactation

Question 20

How does destruction of the hypothalamus or interruption of the hypothalamic-hypophysial tract result in prolactin excess?

Answer 20

loss of inhibition by dopamine

Question 21

why infertility when prolactin excess?

Answer 21

due to GnRH inhibition

galactorrhea, amenorhea, failure to ovulate, decr. libido, dec. spermatogenesis

Question 22

Dopamine agonists?

Answer 22

bromocriptine

Question 22

antipsichotics effect?

Answer 22

inhibits dopamine

Question 22

dopamine antagonists?

Answer 22

most antipsychotics;
estrogen (OCPs, pregnancy)

THEY STIMULATE PROLACTIN PRODUCTION

Question 22

nipple stimulation effect?

Answer 22

inhibits dopamine

Question 23

OCPs/estrogen effect?

Answer 23

tiesiog stimulates production

Question 23

koks dar weird dopamino inhibition mechanizmas?

Answer 23

Chest wall injury (via ANS)

Question 24

Renal failure and prolactin?

Answer 24

Reduced prolatin elimination

Question 25

primary or secondary hypothyroidism effect?

Answer 25

promotes TRH secretion -> incr. prolaction secr.

Question 26

estradiol and progesterone on prolactin during preganacy?

Answer 26

block effect

Question 27

UW. What prolactin level in prolactinoma?

Answer 27

> 200ng/ml

Question 28

UW. if suspect prolactinoma, what other lab test need to do to differentiate?

Answer 28

rule out renal insuff (creatinine) and hypothyroidism (TSH, thyroixine)

Question 29

UW. What size of prolactinoma does not cause mass symtoms?

Answer 29

is less than 1 cm. Do MRI

Question 30

UW. Prolactinoma symptoms in premenopausal?

Answer 30

oligomenorrhea/amenorrhea, infertility, galactorrhea, hot flashes, decr. bone density

Question 31

UW. Prolactinoma symptoms in ppostmenopausal?

Answer 31

mass effect symptoms (headache, visual defects)

Question 32

UW. Prolactinoma symptoms in men?

Answer 32

infertility, decr. libido, impotence, gynecomastia (AKA HYPOGONADISM)